DDR2 Antibody (3B11E4): sc-81707

DDR2 Antibody (3B11E4) is a mouse monoclonal IgG2a kappa light chain antibody that detects DDR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. DDR2 Antibody (3B11E4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DDR2, a member of the discoidin domain receptor family, plays a crucial role in mediating cellular responses to collagen, which is vital for tissue remodeling and repair. Located primarily on the cell surface, DDR2 interacts with collagen fibers, triggering signaling pathways that influence cell adhesion, migration, and differentiation. This interaction is particularly important in wound healing and fibrosis, as DDR2 activation leads to upregulation of matrix metalloproteinase-1, an enzyme that degrades extracellular matrix components. Understanding DDR2 function and signaling mechanisms is essential for elucidating DDR2′s role in various pathological conditions, including cancer and fibrotic diseases, making anti-DDR2 antibody (3B11E4) a valuable tool for researchers studying these processes.

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DDR2 Antibody (3B11E4) References:

1. Growth factors and cancer.  |  Aaronson, SA. 1991. Science. 254: 1146-53. PMID: 1659742
2. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.  |  Huang, E., et al. 1990. Cell. 63: 225-33. PMID: 1698557
3. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.  |  Krämer, H., et al. 1991. Nature. 352: 207-12. PMID: 1857416
4. Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development.  |  Pawson, T. and Bernstein, A. 1990. Trends Genet. 6: 350-6. PMID: 1965067
5. Signal transduction by receptors with tyrosine kinase activity.  |  Ullrich, A. and Schlessinger, J. 1990. Cell. 61: 203-12. PMID: 2158859
6. LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2/β-catenin activation via interacting with hnRNPC.  |  Cai, Y., et al. 2022. J Exp Clin Cancer Res. 41: 335. PMID: 36471363
7. Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins.  |  Schab, AM., et al. 2023. Mol Cancer Res. 21: 1234-1248. PMID: 37527178
8. Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions.  |  Mariadoss, AVA. and Wang, CZ. 2023. Int J Mol Sci. 24: PMID: 37834343
9. DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.  |  Akinjiyan, FA., et al. 2024. Oncogene. 43: 189-201. PMID: 37996700
10. Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.  |  Perez, JL., et al. 1994. Oncogene. 9: 211-9. PMID: 8302582
11. The discoidin domain receptor tyrosine kinases are activated by collagen.  |  Vogel, W., et al. 1997. Mol Cell. 1: 13-23. PMID: 9659899
12. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.  |  Shrivastava, A., et al. 1997. Mol Cell. 1: 25-34. PMID: 9659900

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDR2 Antibody (3B11E4) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-DDR2 Antibody (3B11E4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDR2 Antibody (3B11E4) Specifications

Alternate Product Name: discoidin domain receptor 2

Product Clone Name: 3B11E4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 422-639

Epitope Target: DDR2

Epitope Species: human

Product Reactivity/Detection: DDR2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for DDR2 Antibody (3B11E4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin