Dab2 Antibody (D-6): sc-136963
- Dab2 Antibody (D-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 661-770 of Dab2 of human origin
- recommended for detection of Dab2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dab2 Antibody (D-6) for WB applications. These reagents are now offered in bundles with Dab2 Antibody (D-6) (see ordering information below).
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Dab2 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects Dab2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dab2, also known as DOC-2, is a mitogen-responsive phosphoprotein that plays a crucial role in cellular signaling and growth regulation. Dab2 is primarily located in the cytoplasm and interacts with the SH3 domain of the GRB2 protein, which negatively regulates cell growth and proliferation. Proper functioning of Dab2 is essential for maintaining cellular homeostasis, and dysregulation can lead to various pathological conditions, including cancer. Additionally, Dab2 modulates signaling pathways that influence cell migration and differentiation, making Dab2 a vital component in developmental processes. Through binding to other signaling molecules, Dab2 serves as an important player in cellular communication, highlighting Dab2′s relevance in both normal physiology and disease states.
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Dab2 Antibody (D-6) References:
- Regulation of Dab2 expression in intestinal and renal epithelia by development. | Vázquez-Carretero, MD., et al. 2011. J Cell Biochem. 112: 354-61. PMID: 21080337
- Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β. | Shapira, KE., et al. 2014. Mol Biol Cell. 25: 1620-8. PMID: 24648493
- Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. | Adamson, SE., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 1020-1029. PMID: 29599136
- miR-134-5p Promotes Stage I Lung Adenocarcinoma Metastasis and Chemoresistance by Targeting DAB2. | Zhang, L., et al. 2019. Mol Ther Nucleic Acids. 18: 627-637. PMID: 31689617
- DAB2 suppresses gastric cancer migration by regulating the Wnt/β-catenin and Hippo-YAP signaling pathways. | Wang, H., et al. 2020. Transl Cancer Res. 9: 1174-1184. PMID: 35117462
- DAB2 promotes pulmonary fibrosis and may act as an intermediate between IGF‑1R and PI3K/AKT signaling pathways. | Liang, CL., et al. 2023. Exp Ther Med. 25: 183. PMID: 37021069
- Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis. | Miao, Y., et al. 2024. Biochim Biophys Acta Mol Cell Res. 1871: 119751. PMID: 38776988
- Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing. | Bhattacharjee, S., et al. 2024. bioRxiv.. PMID: 39253510
- Disabled 2 (Dab2) Regulates Tumour Progression in Skin Squamous Cell Carcinoma. | Roy, S., et al. 2024. Exp Dermatol. 33: e70009. PMID: 39503168
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dab2 Antibody (D-6) | sc-136963 | 200 µg/ml | $316.00 | |||
Dab2 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-537381 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dab2 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-534632 | 200 µg Ab; 40 µg BP | $354.00 | |||
Dab2 Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-545167 | 200 µg Ab; 20 µg BP | $354.00 |