Cytokeratin 7 Antibody (LP1K): sc-53263

Cytokeratin 7 Antibody (LP1K) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Cytokeratin 7, also known as KRT7 or sarcolectin. Cytokeratin 7 monoclonal antibody (LP1K) is raised against sonicated cytoskeleton fractions from SV40 transformed neonatal keratinocytes, ensuring precise targeting of the Cytokeratin 7 epitope. Anti-Cytokeratin 7 antibody (LP1K) exhibits broad species reactivity, including mouse, rat, and human, and is suitable for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Cytokeratin 7 is an intermediate filament protein that plays a crucial role in maintaining the structural integrity and resilience of epithelial cells by forming a network of a-helical coiled-coil dimers that assemble into 10 nm diameter filaments. This structural configuration is essential for cellular stability, enabling epithelial cells to withstand mechanical stress and contribute to tissue differentiation and specialization. Additionally, Cytokeratin 7 is involved in cellular processes such as agglutination of normal and transformed cells and modulation of interferon-dependent protein synthesis, which are important for immune responses and cellular homeostasis. The precise localization of Cytokeratin 7 within the cytoskeleton and presence at the cell membrane make Cytokeratin 7 a valuable marker for identifying and characterizing both normal and malignant epithelial cells. Anti-Cytokeratin 7 antibody (LP1K) enables researchers to effectively study epithelial cell biology, monitor differentiation processes, and investigate the molecular mechanisms underlying various cancers.

The preferred Cytokeratin 7 antibody is Cytokeratin 7 Antibody (RCK105): sc-23876.