Cytokeratin 5/8 Antibody (RCK102): sc-32328

Cytokeratin 5/8 Antibody (RCK102) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 5/8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Cytokeratin 5/8 antibody (RCK102) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC), providing flexibility for diverse experimental needs. Cytokeratin 5 and 8 are crucial components of the cytoskeleton in epithelial cells, forming intermediate filaments that contribute to structural integrity and mechanical resilience of tissues. These cytokeratins maintain stability of basal cells in stratified epithelia, essential for barrier function and protection against environmental stressors. Expression patterns of Cytokeratin 5 and 8 serve as valuable biomarkers for distinguishing between different types of epithelial tumors, aiding in diagnosis and characterization of malignancies. Mutations in KRT5 can lead to epidermolysis bullosa, a genetic disorder resulting in fragile skin, highlighting Cytokeratin 5/8′s significance in normal physiology and disease states. Cytokeratin 5 is predominantly expressed in basal cells, while Cytokeratin 8 appears in various epithelial tissues and tumors, including adenocarcinomas, making Cytokeratin 5/8 (RCK102) monoclonal antibody an essential tool for studying epithelial biology and cancer pathology.

The preferred Cytokeratin 5 antibody is Cytokeratin 5 Antibody (RCK103): sc-32721.