Cytokeratin 14 Antibody (RCK107): sc-23878

Cytokeratin 14 Antibody (RCK107) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 14 in mouse, rat, human, porcine, and canine samples through applications such as western blotting (WB) and immunofluorescence (IF). Cytokeratin 14 is a vital component of the cytoskeletal structure in epithelial cells, primarily found in the basal layer of the epidermis, where Cytokeratin 14 plays a crucial role in maintaining cellular integrity and resilience against mechanical stress. Cytokeratin 14 forms heterodimers with other cytokeratins, contributing to the formation of intermediate filaments that provide structural support to keratinocytes. Proper functioning of Cytokeratin 14 is essential for skin health, as mutations in the gene encoding Cytokeratin 14 can lead to epidermolysis bullosa simplex, a genetic disorder characterized by fragile skin that blisters easily. Expression of Cytokeratin 14 is also significant in various skin diseases, including Bowen′s disease, where distinct expression patterns can aid in diagnosis and characterization of malignant tumors. Anti-Cytokeratin 14 antibody (RCK107) serves as an invaluable tool for researchers studying epithelial cell biology, skin disorders, and cancer pathology, allowing detailed analysis in various species.

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Cytokeratin 14 Antibody (RCK107) References:

1. Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours.  |  Chu, PG., et al. 2001. Histopathology. 39: 9-16. PMID: 11454039
2. BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia.  |  Linskey, KR., et al. 2013. Arch Pathol Lab Med. 137: 1591-8. PMID: 24168496
3. Cytokeratin 14 and cytokeratin 18 expressions in reduced enamel epithelium and dentigerous cyst: Possible role in oncofetal transformation and histogenesis- of follicular type of adenomatoid odontogenic tumor.  |  Shruthi, DK., et al. 2014. J Oral Maxillofac Pathol. 18: 365-71. PMID: 25948990
4. Expression of Cytokeratin 14 and 19 in Process of Oral Carcinogenesis.  |  Yoshida, K., et al. 2015. Bull Tokyo Dent Coll. 56: 105-11. PMID: 26084998
5. Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.  |  Gao, XL., et al. 2017. PLoS One. 12: e0171341. PMID: 28152077
6. Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.  |  Li, YP., et al. 2018. Exp Biol Med (Maywood). 243: 344-349. PMID: 29350066
7. Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.  |  Tian, Q., et al. 2021. Hua Xi Kou Qiang Yi Xue Za Zhi. 39: 274-278. PMID: 34041875
8. Visualizing Cytokeratin-14 Levels in Basal-Like Breast Cancer via ImmunoSPECT Imaging.  |  Ji, H., et al. 2022. Mol Pharm. 19: 3542-3550. PMID: 35285645
9. In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.  |  Tiyaboonchai, A., et al. 2023. Dev Biol. 504: 120-127. PMID: 37813160
10. Cytokeratin 14 as a marker of squamous differentiation in transitional cell carcinomas.  |  Harnden, P. and Southgate, J. 1997. J Clin Pathol. 50: 1032-3. PMID: 9516889

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.