Cytokeratin 14 Antibody (LL001): sc-53253

Cytokeratin 14 Antibody (LL001) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cytokeratin 14 in mouse, rat, human, and porcine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 14 antibody (LL001) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 14, also known as KRT14, is a vital component of the cytoskeleton in epithelial cells, playing a crucial role in maintaining cellular integrity and resilience. Cytokeratin 14 is predominantly located in the basal layer of the epidermis, forming part of the intermediate filament network that provides mechanical support and stability to keratinocytes. Cytokeratin 14 expression helps protect against mechanical stress and contributes to the skin′s barrier function. Mutations in Cytokeratin 14 can lead to conditions such as epidermolysis bullosa simplex, a genetic disorder characterized by skin fragility and blistering. Cytokeratin 14 serves as a marker for epithelial differentiation and aids in diagnosing various skin malignancies, including Bowen′s disease, where expression patterns can indicate neoplastic changes. Human Cytokeratin 14 gene is located on chromosome 17q12-21, highlighting significance in both normal physiology and disease states.

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Cytokeratin 14 Antibody (LL001) References:

1. Patterns of basal cell keratin 14 expression in Bowen's disease: a possible marker for tumour progression.  |  Komine, M., et al. 2001. Br J Dermatol. 145: 223-8. PMID: 11531783
2. Epidermolysis bullosa simplex: evidence in two families for keratin gene abnormalities.  |  Bonifas, JM., et al. 1991. Science. 254: 1202-5. PMID: 1720261
3. A group of type I keratin genes on human chromosome 17: characterization and expression.  |  Rosenberg, M., et al. 1988. Mol Cell Biol. 8: 722-36. PMID: 2451124
4. Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk.  |  Leifert, WR., et al. 2015. J Alzheimers Dis. 48: 443-52. PMID: 26402008
5. Hyperacetylation of Microtubules in Mesenchymal Cells Increases Cytokeratin 14-Positive Epithelial Progenitors in Developing Salivary Glands.  |  Joo, EE., et al. 2016. J Dent Res. 95: 1518-1527. PMID: 27542391
6. A human keratin 14 'knockout': the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein.  |  Chan, Y., et al. 1994. Genes Dev. 8: 2574-87. PMID: 7525408
7. Keratin 14 gene mutations in patients with epidermolysis bullosa simplex.  |  Chen, H., et al. 1995. J Invest Dermatol. 105: 629-32. PMID: 7561171
8. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview.  |  van der Velden, LA., et al. 1993. Head Neck. 15: 133-46. PMID: 7680025
9. Serum and tissue distribution of a fragment of cytokeratin 19 (cyfra 21-1) in lung cancer patients.  |  Quillien, V., et al. 1995. Anticancer Res. 15: 2857-63. PMID: 8669879
10. Keratins and the skin.  |  Fuchs, E. 1995. Annu Rev Cell Dev Biol. 11: 123-53. PMID: 8689554
11. Functional inactivation of p53 by antisense RNA induces invasive ability of lung carcinoma cells and downregulates cytokeratin synthesis.  |  Mukhopadhyay, T. and Roth, JA. 1996. Anticancer Res. 16: 1683-9. PMID: 8712687
12. Cytokeratin expression, fibrillar organization, and subtle function in liver cells.  |  Marceau, N. and Loranger, A. 1995. Biochem Cell Biol. 73: 619-25. PMID: 8714681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 14 Antibody (LL001) has 127 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 14 Antibody (LL001) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 14 Antibody (LL001) Specifications

Alternate Product Name: KRT14

Product Clone Name: LL001

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 14

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 14

Species Reactivity/Detection: mouse, rat, human, porcine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 127 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 14 Antibody (LL001): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin