Cytokeratin 14 Inhibitors
Common Cytokeratin 14 Inhibitors include, but are not limited to Amodiaquine CAS 86-42-0, Carbonyl Cyanide m-Chlorophenylhydrazone CAS 555-60-2, Clioquinol CAS 130-26-7, E-64 CAS 66701-25-5 and Geldanamycin CAS 30562-34-6.
Cytokeratin 14 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the Cytokeratin 14 (CK14) protein. CK14 is a type I intermediate filament protein and a member of the cytokeratin family, which are structural proteins found in epithelial cells. CK14 is particularly abundant in stratified epithelia, including the skin, oral mucosa, and hair follicles. It plays a crucial role in providing structural support and mechanical integrity to these tissues. CK14 is also considered a marker for specific cell types, such as basal keratinocytes in the skin.
Cytokeratin 14 inhibitors work by specifically targeting the CK14 protein, interfering with its role in maintaining the cytoskeleton and cell structure in stratified epithelial tissues. By doing so, these inhibitors may modulate cellular processes that depend on CK14, impacting tissue development and maintenance. Research into CK14 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in cellular physiology and tissue function. The study of cytokeratin 14 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing tissue architecture and cellular organization in different epithelial tissues.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine is a lysosomotropic agent that alters lysosome function, affecting Cytokeratin 14 degradation and cellular trafficking. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP is a mitochondrial uncoupler that disrupts the proton gradient across the mitochondrial membrane, impacting Cytokeratin 14-related cellular processes. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Clioquinol chelates metal ions, leading to decreased metal-dependent Cytokeratin 14-related signaling pathways and cellular functions. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 inhibits cysteine proteases, which are involved in Cytokeratin 14 processing and turnover, leading to reduced Cytokeratin 14 levels. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is an HSP90 inhibitor, interfering with Cytokeratin 14 folding and stability by disrupting the chaperone function of HSP90. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a non-steroidal anti-inflammatory drug that affects Cytokeratin 14 expression and function via its influence on inflammatory pathways. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN93 is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, modulating Cytokeratin 14 phosphorylation and downstream signaling cascades. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor, altering DNA topology and affecting Cytokeratin 14 gene regulation and transcription. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $134.00 | 12 | |
NSC 87877 is a Src family kinase inhibitor, impacting Cytokeratin 14-related cell signaling and cytoskeletal dynamics. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB activation, leading to reduced Cytokeratin 14 expression and its downstream effects on cell survival and inflammation. | ||||||