Cytokeratin 10/13 Antibody (0.N.355): sc-70909
- Cytokeratin 10/13 Antibody (0.N.355) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against Cytoskeletal preparation extracted from human ectocervical epithelium
- recommended for detection of Cytokeratin 10 and Cytokeratin 13 of human origin by WB, IP, IF and IHC(P); specific for Cytokeratin 13 by IHC(P)
- See Cytokeratin 10 (LH2): sc-53252 for Cytokeratin 10/13 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cytokeratin 10/13 Antibody (0.N.355) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 10/13 Antibody (0.N.355) (see ordering information below).
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Cytokeratin 10/13 Antibody (0.N.355) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 10/13 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 10 and 13 are crucial components of the cytoskeletal structure in epithelial cells, primarily located in the intermediate filaments, where these proteins contribute to mechanical resilience and tissue integrity. Expression of Cytokeratin 10 and 13 is particularly significant in the differentiation of keratinized and non-keratinized epithelial tissues, making these proteins valuable markers for identifying specific types of epithelial cells and their states. Cytokeratin 10 is often associated with the differentiation of squamous epithelial cells, while Cytokeratin 13 is typically expressed in the more basal layers of stratified squamous epithelium. Anti-Cytokeratin 10/13 antibody (0.N.355) accurately identifies these proteins, aiding in the characterization of various malignant tumors, including squamous cell carcinomas and adenocarcinomas, thereby providing essential insights into tumor biology and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 10/13 Antibody (0.N.355) References:
- Chromosomal mapping of human cytokeratin 13 gene (KRT13). | Romano, V., et al. 1992. Genomics. 14: 495-7. PMID: 1385306
- Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence. | Yanagawa, T., et al. 2007. J Exp Clin Cancer Res. 26: 215-20. PMID: 17725101
- Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas. | Ohta, K., et al. 2010. Oncol Rep. 24: 9-14. PMID: 20514438
- Evaluation of superficial oral squamous cell malignancy based on morphometry and immunoexpression of cytokeratin 13 and cytokeratin 17. | Yamashina, M., et al. 2014. Acta Cytol. 58: 67-75. PMID: 24247036
- Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10. | Rieger, M. and Franke, WW. 1988. J Mol Biol. 204: 841-56. PMID: 2464696
- Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker. | Zhu, B., et al. 2018. Biotechnol Lett. 40: 765-772. PMID: 29605938
- Combined loss of expression of involucrin and cytokeratin 13 is associated with poor prognosis in squamous cell carcinoma of mobile tongue. | Pandey, S., et al. 2021. Head Neck. 43: 3374-3385. PMID: 34338386
- Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis. | Yasuda, T., et al. 2022. PLoS One. 17: e0265687. PMID: 35320820
- Clinicopathological comparison and cytokeratin-10 expression between Lichen planus and oral lichenoid lesions. | Moreira, MD., et al. 2024. Arch Oral Biol. 171: 106166. PMID: 39742549
- Coordinate control of growth and cytokeratin 13 expression by retinoic acid. | Kim, SY., et al. 1996. Mol Carcinog. 16: 6-11. PMID: 8634095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 10/13 Antibody (0.N.355) | sc-70909 | 200 µg/ml | $322.00 | |||
Cytokeratin 10/13 Antibody (0.N.355): m-IgG Fc BP-HRP Bundle | sc-537198 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 10/13 Antibody (0.N.355): m-IgGκ BP-HRP Bundle | sc-534405 | 200 µg Ab; 40 µg BP | $361.00 | |||
Cytokeratin 10/13 Antibody (0.N.355): m-IgG2a BP-HRP Bundle | sc-547939 | 200 µg Ab; 10 µg BP | $361.00 |