cyclin A Antibody (E67.1): sc-53230

Cyclin A Antibody (E67.1) is a mouse monoclonal IgG2a antibody that detects cyclin A in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the S phase, where cyclin A is crucial for the proper progression and timing of DNA replication. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive the cell cycle forward. Precise localization of cyclin A is essential, as cyclin A ensures that the cell cycle machinery is activated at the right time and place, preventing errors that could lead to genomic instability or uncontrolled cell proliferation. Cyclin A is also known to interact with various proteins, including the retinoblastoma protein and transcription factors such as E2F, highlighting cyclin A′s importance in cell cycle regulation and potential implications in cancer biology. Anti-cyclin A antibody (E67.1) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation and transformation.

The preferred cyclin A antibody is cyclin A Antibody (BF683): sc-239.