cyclin A Antibody (BF683): sc-239

Cyclin A Antibody (BF683) is a mouse monoclonal IgE antibody that detects cyclin A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), kinase assays, and enzyme-linked immunosorbent assay (ELISA). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the transition from the S phase to mitosis, making cyclin A essential for proper cell division and proliferation. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinases, particularly Cdk2, to facilitate the progression of the cell cycle. Nuclear localization of cyclin A is crucial as cyclin A allows for the timely activation of target proteins necessary for DNA replication and cell cycle progression. Furthermore, cyclin A has been shown to interact with various proteins, including the retinoblastoma protein and transcription factors such as E2F, which are vital for regulating gene expression during the cell cycle. The presence of cyclin A in these complexes underscores cyclin A′s importance in cell cycle control and potential implications in oncogenesis when dysregulated. Anti-cyclin A antibody (BF683) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs.

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cyclin A Antibody (BF683) References:

1. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.  |  Lees, E., et al. 1992. Genes Dev. 6: 1874-85. PMID: 1398067
2. Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.  |  Williams, RT., et al. 1992. Oncogene. 7: 423-32. PMID: 1532245
3. Cyclin A and the retinoblastoma gene product complex with a common transcription factor.  |  Bandara, LR., et al. 1991. Nature. 352: 249-51. PMID: 1830372
4. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.  |  Wang, J., et al. 1990. Nature. 343: 555-7. PMID: 1967822
5. Cyclin is a component of maturation-promoting factor from Xenopus.  |  Gautier, J., et al. 1990. Cell. 60: 487-94. PMID: 1967981
6. Acetylation of cyclin A: a new cell cycle regulatory mechanism.  |  Mateo, F., et al. 2010. Biochem Soc Trans. 38: 83-6. PMID: 20074040
7. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.  |  Pines, J. and Hunter, T. 1990. Nature. 346: 760-3. PMID: 2143810
8. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF.  |  Draetta, G., et al. 1989. Cell. 56: 829-38. PMID: 2538242
9. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.  |  Giordano, A., et al. 1989. Cell. 58: 981-90. PMID: 2570639
10. Structural basis for the ORC1-Cyclin A association.  |  Wang, B. and Song, J. 2019. Protein Sci. 28: 1727-1733. PMID: 31309634
11. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.  |  Yang, R., et al. 1997. Cancer Res. 57: 913-20. PMID: 9041194
12. Cyclin A: function and expression during cell proliferation.  |  Desdouets, C., et al. 1995. Prog Cell Cycle Res. 1: 115-23. PMID: 9552357

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cyclin A Antibody (BF683) has 288 citations in a variety of scientific publications.

Primary antibodies like Anti-cyclin A Antibody (BF683) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cyclin A Antibody (BF683) Specifications

Alternate Product Name: cyclin A

Product Clone Name: BF683

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgE

Amino Acids:

Epitope Target: cyclin A

Epitope Species: human

Product Reactivity/Detection: cyclin A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, KA, ELISA

Vialing Information: Each vial contains 200 µg IgE in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 288 citations in various scientific publications

Available Conjugates/Forms for cyclin A Antibody (BF683): AC: Agarose, PE: Phycoerythrin, X: TransCruz Reagent