cyclin A Antibody (E23.1): sc-53228
- cyclin A Antibody (E23.1) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- raised against bovine cyclin A fusion protein
- recommended for detection of cyclin A of mouse, rat, human and bovine origin by WB, IP and IF
- See cyclin A (B-8): sc-271682 for cyclin A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin A Antibody (E23.1) for WB applications. These reagents are now offered in bundles with cyclin A Antibody (E23.1) (see ordering information below).
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Cyclin A Antibody (E23.1) is a mouse monoclonal IgG2a antibody that detects cyclin A in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cyclin A plays a pivotal role in regulating the eukaryotic cell cycle, particularly during S phase, where cyclin A is crucial for proper DNA replication progression. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive cell cycle transitions. Nuclear localization of cyclin A ensures precise cell cycle machinery regulation, preventing premature or inappropriate cell division, which can lead to oncogenesis. Cyclin A has been implicated in various cellular processes, including cell transformation, and interacts with key regulatory proteins such as E1A, transcription factors DRTF1 and E2F, and retinoblastoma protein, p110. Anti-cyclin A antibody (E23.1) serves as an essential tool for researchers studying cell cycle dynamics and molecular mechanisms underlying cell proliferation and differentiation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin A Antibody (E23.1) References:
- Degradation of cyclin A is regulated by acetylation. | Mateo, F., et al. 2009. Oncogene. 28: 2654-66. PMID: 19483727
- Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. | Kalaszczynska, I., et al. 2009. Cell. 138: 352-65. PMID: 19592082
- Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. | Kabeche, L. and Compton, DA. 2013. Nature. 502: 110-3. PMID: 24013174
- Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication. | Copeland, NA., et al. 2015. J Cell Sci. 128: 1518-27. PMID: 25736292
- Cyclin A in nonfunctioning pituitary adenomas. | Lamback, EB., et al. 2020. Endocrine. 70: 380-387. PMID: 32621052
- Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells. | Dumitru, AMG. and Compton, DA. 2022. Methods Mol Biol. 2415: 175-182. PMID: 34972954
- Skp2-Cyclin A Interaction Is Necessary for Mitotic Entry and Maintenance of Diploidy. | Vasavan, B., et al. 2024. J Mol Biol. 436: 168505. PMID: 38423454
- [Cyclin A: a good markers for the study of cell cycle control and tumor progression?]. | Philips, A., et al. 1998. C R Seances Soc Biol Fil. 192: 223-30. PMID: 9759365
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin A Antibody (E23.1) | sc-53228 | 200 µg/ml | $322.00 | |||
cyclin A Antibody (E23.1): m-IgG Fc BP-HRP Bundle | sc-536910 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin A Antibody (E23.1): m-IgGκ BP-HRP Bundle | sc-534083 | 200 µg Ab; 40 µg BP | $361.00 | |||
cyclin A Antibody (E23.1): m-IgG2a BP-HRP Bundle | sc-547898 | 200 µg Ab; 10 µg BP | $361.00 |