CUL-7 Antibody (H-8): sc-514970
- CUL-7 Antibody (H-8) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1661-1680 at the C-terminus of CUL-7 of human origin
- recommended for detection of CUL-7 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CUL-7 Antibody (H-8). This work is in progress.
CUL-7 Antibody (H-8) is a mouse monoclonal IgM antibody that detects CUL-7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CUL-7 plays a crucial role in the ubiquitin-proteasome pathway, specifically mediating the selective targeting of proteins for ubiquitin-mediated proteolysis as part of an SCF-like complex that includes RBX1, SKP1, FBXW8, and GLMN isoform 1. This complex is essential for the degradation of proteins involved in cellular proliferation and differentiation, highlighting CUL-7′s importance in maintaining cellular homeostasis and regulating developmental processes. CUL-7 is predominantly expressed in fetal kidney and adult skeletal muscle, with significant levels also found in the fetal brain, adult pancreas, kidney, placenta, and heart, as well as in various cell types such as trophoblasts, lymphoblasts, osteoblasts, chondrocytes, and skin fibroblasts. Notably, defects in the gene encoding CUL-7 are linked to 3-M syndrome, an autosomal recessive disorder characterized by severe growth retardation and distinct skeletal abnormalities, underscoring CUL-7′s critical role in normal development and health. Anti-CUL-7 antibody (H-8) is an invaluable tool for researchers investigating the mechanisms of protein degradation and the implications of CUL-7 in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUL-7 Antibody (H-8) | sc-514970 | 200 µg/ml | $316.00 | |||
CUL-7 (H-8) Neutralizing Peptide | sc-514970 P | 100 µg/0.5 ml | $68.00 |