CSN8 Antibody (H-11): sc-398886

CSN8 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects CSN8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN8 is a crucial component of the COP9 signalosome complex, which plays a significant role in regulating various developmental and cellular processes. This complex is composed of several proteins, including CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7a, CSN7b, and CSN8, and is essential for mediating the deneddylation of SCF-type E3 ligase complexes, thereby influencing the ubiquitin conjugation pathway. CSN8′s importance lies not only in its structural role within the complex but also in its involvement in the phosphorylation of key proteins such as p53, c-Jun, IκBα, and IRF-8. These phosphorylation events are critical for regulating cellular responses to stress and maintaining protein homeostasis, as they can either promote degradation or protect proteins from degradation by the ubiquitin-proteasome system. CSN8′s ability to modulate these pathways highlights its significance in cellular signaling and the potential implications in various diseases, making anti-CSN8 antibody (H-11) an invaluable tool for researchers studying these complex mechanisms.

The preferred CSN8 antibody is CSN8 Antibody (F-8): sc-393482.