CSN7a Antibody (H-2): sc-514067

CSN7a Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects CSN7a in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSN7a is a crucial component of the COP9 signalosome complex, which plays a significant role in regulating various developmental and cellular processes. CSN7a is primarily located in the cytoplasm and nucleus, where CSN7a participates in the deneddylation of SCF-type E3 ligase complexes, thereby modulating the ubiquitin conjugation pathway. CSN7a′s cellular localization influences the stability and degradation of key regulatory proteins, such as p53 and c-Jun, which are vital for cell cycle control and apoptosis. CSN7a undergoes phosphorylation by casein kinase 2 (CK2), which can further impact CSN7a′s interactions with other components of the COP9 signalosome, including CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7a′s intricate interplay with these proteins underscores CSN7a′s essential role in maintaining cellular homeostasis and responding to stress signals, making CSN7a a valuable target for research in cancer and developmental biology.

The preferred CSN7a antibody is CSN7a Antibody (D-6): sc-398882.