Csk Antibody (B-7): sc-166513
- Csk Antibody (B-7) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-17 at the N-terminus of Csk of human origin
- recommended for detection of Csk of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Csk Antibody (B-7) for WB applications. These reagents are now offered in bundles with Csk Antibody (B-7) (see ordering information below).
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Csk Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects Csk in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Csk, or C-terminal Src kinase, plays a crucial role in regulating Src family tyrosine kinases, which are essential for various cellular processes, including growth, differentiation, and survival. By phosphorylating the tyrosine residue Y527 on Src, Csk effectively downregulates Src activity, thereby maintaining cellular homeostasis and preventing uncontrolled cell proliferation. This regulatory mechanism is vital, as dysregulation of Src activity is often implicated in cancer and other diseases. Anti-Csk antibody (B-7) provides a reliable tool for researchers studying the intricate signaling pathways involving Src family kinases, enabling insights into their roles in health and disease.
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Csk Antibody (B-7) References:
- Small molecule inhibition of Csk alters affinity recognition by T cells. | Manz, BN., et al. 2015. Elife. 4: PMID: 26302204
- Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure. | Lee, HJ., et al. 2016. PLoS One. 11: e0146841. PMID: 26751575
- Csk/Src/EGFR signaling regulates migration of myofibroblasts and alveolarization. | Li, J., et al. 2016. Am J Physiol Lung Cell Mol Physiol. 310: L562-71. PMID: 26773066
- SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. | Cui, N., et al. 2019. Neoplasia. 21: 676-688. PMID: 31125786
- Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice. | Nagy, Z., et al. 2020. Blood. 135: 1574-1587. PMID: 32016283
- CSK promotes innate immune response to DNA virus by phosphorylating MITA. | Gao, P., et al. 2020. Biochem Biophys Res Commun. 526: 199-205. PMID: 32201077
- Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway. | Lu, W., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34675079
- Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism. | Zhang, X., et al. 2023. BMC Med. 21: 197. PMID: 37237266
- Discovery of potent CSK inhibitors through integrated virtual screening and molecular dynamic simulation. | Chen, R., et al. 2024. Arch Pharm (Weinheim). 357: e2400066. PMID: 38809025
- The Src and Csk families of tyrosine protein kinases in hemopoietic cells. | Chow, LM. and Veillette, A. 1995. Semin Immunol. 7: 207-26. PMID: 8520026
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Csk Antibody (B-7) | sc-166513 | 200 µg/ml | $322.00 | |||
Csk Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-537498 | 200 µg Ab; 10 µg BP | $361.00 | |||
Csk Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-534780 | 200 µg Ab; 40 µg BP | $361.00 | |||
Csk Antibody (B-7): m-IgG2a BP-HRP Bundle | sc-548033 | 200 µg Ab; 10 µg BP | $361.00 | |||
Csk (B-7) Neutralizing Peptide | sc-166513 P | 100 µg/0.5 ml | $69.00 |