CREM Antibody (D-5): sc-390425

CREM Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect the cAMP response element modulator (CREM). Anti-CREM antibody (D-5) targets the N-terminal region of CREM, specifically amino acids 1-153, and is effective in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CREM is a pivotal transcription factor within the ATF/CREB family, playing a crucial role in regulating gene expression in response to cAMP signaling pathways. The function of CREM is essential for processes such as spermatogenesis, where CREM activity is vital for male fertility, as demonstrated by infertility in male mice lacking a functional CREM gene. Additionally, CREM regulates immune responses and neuronal functions, highlighting its importance in both reproductive biology and broader physiological contexts. By modulating the transcription of target genes, CREM influences cellular differentiation, proliferation, and apoptosis, making CREM a key player in maintaining cellular homeostasis. CREM (D-5) antibody shows reactivity with CREM proteins from rat and human origins, broadening its utility for cross-species studies and enhancing its applicability in diverse research settings. Anti-CREM antibody (D-5) enables precise investigation of CREM′s functional mechanisms, facilitating a deeper understanding of its role in various signaling pathways and its impact on health and disease.

The preferred CREB1 antibody is CREB1 Antibody (D-12): sc-377154.