CPVL Antibody (H-7): sc-376658

CPVL Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects CPVL of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CPVL antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CPVL, or carboxypeptidase, vitellogenic-like, is a serine carboxypeptidase that plays a crucial role in the immune system, particularly in myeloid cells. CPVL (H-7) antibody targets a protein primarily located in the cytoplasm of these cells, which allows for efficient processing of peptides during immune responses. CPVL is involved in the maturation of monocytes into macrophages, suggesting importance in phagocytosis and antigen processing, thereby contributing to the organization of the innate immune response. Additionally, CPVL contains four putative N-glycosylation sites and a serine carboxypeptidase active site, which are essential for enzymatic activity and stability. These modifications can influence protein function and interactions, making CPVL a vital component in understanding immune regulation and potential therapeutic targets.

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CPVL Antibody (H-7) References:

1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages.  |  Mahoney, JA., et al. 2001. Genomics. 72: 243-51. PMID: 11401439
2. Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis.  |  Stanton, LA., et al. 2003. Int J Exp Pathol. 84: 289-304. PMID: 14748748
3. Characterization of a serine carboxypeptidase in the salivary glands and fat body of the orange wheat blossom midge, Sitodiplosis mosellana (Diptera: Cecidomyiidae).  |  Mittapalli, O., et al. 2006. Insect Biochem Mol Biol. 36: 154-60. PMID: 16431282
4. A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles.  |  Harris, J., et al. 2006. Int J Exp Pathol. 87: 29-39. PMID: 16436111
5. Tissue expression of the novel serine carboxypeptidase Scpep1.  |  Lee, TH., et al. 2006. J Histochem Cytochem. 54: 701-11. PMID: 16461364
6. Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins.  |  Sleat, DE., et al. 2006. Mol Cell Proteomics. 5: 1942-56. PMID: 16709564

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CPVL Antibody (H-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CPVL Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CPVL Antibody (H-7) Specifications

Alternate Product Name: CPVL

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 147-193

Epitope Target: CPVL

Epitope Species: human

Product Reactivity/Detection: CPVL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CPVL Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin