Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CPSF4 (Cleavage and polyadenylation specificity factor subunit 4, NS1 effector domain-binding protein 1) is a nuclear protein that belongs to the CPSF4/YTH1 family and contains five C3H1-type zinc fingers and one CCHC-type zinc finger. CPSF4 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3′-end formation. CPSF is a multisubunit factor consisting of four subunits. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. The largest subunit of CPSF can, by itself, bind preferentially to AAUAAA-containing RNAs and binds specifically to both the suppressor of forked subunit of the cleavage stimulatory factor (CstF) and to poly (A) polymerase. snRNPA protein (U1 snRNP-A) interacts with and affects the activity of CPSF by stabilizing the interaction of CPSF with the AAUAAA-containing RNAs to increase the efficiency of polyadenylation. Efficient processing of 3′ core poly(A) site also requires specific sequences located 76 nucleotides upstream of the AAUAAA hexamer.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.