CPB Antibody (D-3): sc-271869
- CPB Antibody (D-3) is a mouse monoclonal IgG1 κ CPB antibody provided at 200 µg/ml
- raised against amino acids 306-358 mapping within an internal region of CPB of human origin
- CPB Antibody (D-3) is recommended for detection of CPB of mouse, rat, human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CPB Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CPB Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with CPB Antibody (D-3) (see ordering information below).
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CPB Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CPB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CPB Antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CPB protein, also known as carboxypeptidase B, CPB1, or pancreas-specific protein, is a zinc-containing exopeptidase that plays a crucial role in digestion by cleaving C-terminal basic amino acid residues from protein substrates. This enzymatic activity is vital for proper digestion of dietary proteins and regulation of various physiological processes. CPB is synthesized as an inactive zymogen in the endoplasmic reticulum of pancreatic acinar cells, where CPB is packaged into secretory granules and released into the duodenum upon stimulation. In the duodenum, CPB is activated through cleavage of its N-terminal activation peptide, allowing CPB to perform digestive functions. CPB serves as a significant serum marker for acute pancreatitis and pancreatic graft rejection, making anti-CPB antibody (D-3) an essential tool for research and clinical diagnostics in understanding pancreatic health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CPB Antibody (D-3) References:
- Investigations of the in-vitro metabolism of three opioid tetrapeptides by pancreatic and intestinal enzymes. | Krondahl, E., et al. 2000. J Pharm Pharmacol. 52: 785-95. PMID: 10933129
- Trypsin-based laboratory methods and carboxypeptidase activation peptide in acute pancreatitis. | Kylänpää-Bäck, ML., et al. 2002. JOP. 3: 34-48. PMID: 11884765
- Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic diseases. | Müller, CA., et al. 2002. Gut. 51: 229-35. PMID: 12117885
- Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). | Barbosa Pereira, PJ., et al. 2002. J Mol Biol. 321: 537-47. PMID: 12162965
- Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. | Yamamoto, KK., et al. 1992. J Biol Chem. 267: 2575-81. PMID: 1370825
- Human pancreas-specific protein/procarboxypeptidase B: a useful serum marker of acute pancreatitis. | Pezzilli, R., et al. 1994. Digestion. 55: 73-7. PMID: 7514550
- Isoforms of procarboxypeptidase B, (pancreas-specific protein, PASP) in human serum, pancreatic tissue and juice. | Fernstad, R., et al. 1993. Scand J Clin Lab Invest Suppl. 213: 9-17. PMID: 8322019
- Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. | Aloy, P., et al. 1998. Biol Chem. 379: 149-55. PMID: 9524066
- The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. | Rau, B., et al. 1998. Pancreas. 17: 134-9. PMID: 9700943
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPB Antibody (D-3) | sc-271869 | 200 µg/ml | $322.00 | |||
CPB Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-529276 | 200 µg Ab; 10 µg BP | $361.00 | |||
CPB Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-522085 | 200 µg Ab, 40 µg BP | $361.00 | |||
CPB Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-543429 | 200 µg Ab; 20 µg BP | $361.00 | |||
CPB Antibody (D-3) AC | sc-271869 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CPB Antibody (D-3) HRP | sc-271869 HRP | 200 µg/ml | $322.00 | |||
CPB Antibody (D-3) FITC | sc-271869 FITC | 200 µg/ml | $336.00 | |||
CPB Antibody (D-3) PE | sc-271869 PE | 200 µg/ml | $349.00 | |||
CPB Antibody (D-3) Alexa Fluor® 488 | sc-271869 AF488 | 200 µg/ml | $364.00 | |||
CPB Antibody (D-3) Alexa Fluor® 546 | sc-271869 AF546 | 200 µg/ml | $364.00 | |||
CPB Antibody (D-3) Alexa Fluor® 594 | sc-271869 AF594 | 200 µg/ml | $364.00 | |||
CPB Antibody (D-3) Alexa Fluor® 647 | sc-271869 AF647 | 200 µg/ml | $364.00 | |||
CPB Antibody (D-3) Alexa Fluor® 680 | sc-271869 AF680 | 200 µg/ml | $364.00 | |||
CPB Antibody (D-3) Alexa Fluor® 790 | sc-271869 AF790 | 200 µg/ml | $364.00 |