COL7A1 Antibody (LH7.2): sc-53226

COL7A1 Antibody (LH7.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Collagen Type VII in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-COL7A1 antibody (LH7.2) is offered in a non-conjugated form, allowing for versatile experimental design. Collagen Type VII is a crucial component of the extracellular matrix, primarily found in the anchoring fibrils of the dermal-epidermal junction, where COL7A1 plays a vital role in skin integrity and wound healing. Collagen Type VII is essential for maintaining the structural stability of the skin, as COL7A1 helps anchor the epidermis to the underlying dermis, thereby preventing blister formation. Mutations in the COL7A1 gene can lead to dystrophic epidermolysis bullosa, a severe skin disorder characterized by fragile skin and blistering. The unique triple helix structure of Collagen Type VII, which allows for tensile strength and stability, is critical for function in tissue architecture. COL7A1 monoclonal antibody (LH7.2) enables valuable insights into the role of Collagen Type VII in various biological processes and disease states.

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COL7A1 Antibody (LH7.2) References:

1. Meganuclease-Mediated COL7A1 Gene Correction for Recessive Dystrophic Epidermolysis Bullosa.  |  Izmiryan, A., et al. 2016. J Invest Dermatol. 136: 872-875. PMID: 26897595
2. Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination.  |  Kocher, T., et al. 2019. Mol Ther Nucleic Acids. 18: 496-507. PMID: 31670199
3. Prognostic Value of Highly Expressed Type VII Collagen (COL7A1) in Patients With Gastric Cancer.  |  Oh, SE., et al. 2021. Pathol Oncol Res. 27: 1609860. PMID: 34512204
4. Therapeutic base editing and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa.  |  Hong, SA., et al. 2022. Mol Ther. 30: 2664-2679. PMID: 35690907
5. COL7A1 Homozygous Arg2471Ter Mutation Leads to the Severe Phenotype of Autosomal Recessive Dystrophic Epidermolysis Bullosa in the Fetus.  |  Zhao, X., et al. 2023. Mol Syndromol. 13: 511-516. PMID: 36660025
6. Identification of a novel COL7A1 variant associated with dystrophic epidermolysis bullosa pruriginosa responding effectively to dupilumab.  |  Zhao, C., et al. 2023. Mol Genet Genomic Med. 11: e2258. PMID: 37676173
7. Genetic diagnosis of a rare COL7A1 variant causing dystrophic epidermolysis bullosa pruriginosa through whole‑exome sequencing.  |  Yang, Y., et al. 2023. Exp Ther Med. 26: 502. PMID: 37822584
8. CRISPR/Cas9-Mediated Generation of COL7A1-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa.  |  Alipour, F., et al. 2023. Cell J. 25: 665-673. PMID: 37865875
9. Recessive dystrophic epidermolysis bullosa caused by a novel COL7A1 variant with isodisomy.  |  Niida, Y., et al. 2023. Hum Genome Var. 10: 29. PMID: 37985760
10. A case of epidermolysis bullosa pruriginosa with a COL7A1 gene mutation successfully treated with upadacitinib.  |  Guo, L., et al. 2025. J Dermatol. 52: e5-e7. PMID: 38660959

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL7A1 Antibody (LH7.2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-COL7A1 Antibody (LH7.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL7A1 Antibody (LH7.2) Specifications

Alternate Product Name: COL7A1

Product Clone Name: LH7.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: COL7A1

Epitope Species: human

Product Reactivity/Detection: Collagen Type VII

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for COL7A1 Antibody (LH7.2): N/A

The preferred COL7A1 antibody is COL7A1 Antibody (4D2): sc-33710.