COL7A1 Antibody (4D2): sc-33710
- COL7A1 Antibody (4D2) is a mouse monoclonal IgG1 κ COL7A1 antibody, cited in 23 publications, provided at 200 µg/ml
- raised against SDS-insoluble proteins of normal human skin
- COL7A1 Antibody (4D2) is recommended for detection of Collagen Type VII of human origin by WB, IP, IF and IHC(P)
- Anti-COL7A1 Antibody (4D2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for COL7A1 Antibody (4D2) for WB and IHC(P) applications. These reagents are now offered in bundles with COL7A1 Antibody (4D2) (see ordering information below).
COL7A1 Antibody (4D2) is a mouse monoclonal IgG1 kappa light chain antibody that detects COL7A1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-COL7A1 antibody (4D2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COL7A1, also known as type VII collagen, plays a crucial role in forming anchoring fibrils that connect the epidermis to the dermis, providing structural integrity to the skin. COL7A1 is primarily located in the basement membrane zone, where COL7A1 is essential for maintaining skin stability and resilience against mechanical stress. Mutations in the COL7A1 gene can lead to dystrophic epidermolysis bullosa, a severe skin blistering disorder, highlighting COL7A1′s importance in skin health and disease. Understanding COL7A1′s function and localization is vital for developing therapeutic strategies for conditions associated with COL7A1′s dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COL7A1 Antibody (4D2) References:
- Collagen and bone strength. | Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
- Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways. | Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
- ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation. | Sheriff, A., et al. 2022. Sci Rep. 12: 19643. PMID: 36385635
- COL7A1 Editing via RNA Trans-Splicing in RDEB-Derived Skin Equivalents. | Liemberger, B., et al. 2023. Int J Mol Sci. 24: PMID: 36901775
- Cytosine Deaminase Base Editing to Restore COL7A1 in Dystrophic Epidermolysis Bullosa Human: Murine Skin Model. | Naso, G., et al. 2023. JID Innov. 3: 100191. PMID: 37213713
- COL7A1 Expression Improves Prognosis Prediction for Patients with Clear Cell Renal Cell Carcinoma Atop of Stage. | Koca, D., et al. 2023. Cancers (Basel). 15: PMID: 37345040
- Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation. | Pan, C., et al. 2024. J Control Release. 370: 82-94. PMID: 38643938
- The COL7A1/PI3K/AKT axis regulates the progression of cholangiocarcinoma. | Ma, Y., et al. 2024. Heliyon. 10: e37361. PMID: 39309925
- Cell adhesion to collagenous matrices. | McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
- Versatile collagens in invertebrates. | Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
- The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. | Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL7A1 Antibody (4D2) | sc-33710 | 200 µg/ml | $316.00 | |||
COL7A1 Antibody (4D2): m-IgG Fc BP-HRP Bundle | sc-526709 | 200 µg Ab; 10 µg BP | $354.00 | |||
COL7A1 Antibody (4D2): m-IgG1 BP-HRP Bundle | sc-532082 | 200 µg Ab; 20 µg BP | $354.00 | |||
COL7A1 Antibody (4D2) AC | sc-33710 AC | 500 µg/ml, 25% agarose | $416.00 | |||
COL7A1 Antibody (4D2) HRP | sc-33710 HRP | 200 µg/ml | $316.00 | |||
COL7A1 Antibody (4D2) FITC | sc-33710 FITC | 200 µg/ml | $330.00 | |||
COL7A1 Antibody (4D2) PE | sc-33710 PE | 200 µg/ml | $343.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 488 | sc-33710 AF488 | 200 µg/ml | $357.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 546 | sc-33710 AF546 | 200 µg/ml | $357.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 594 | sc-33710 AF594 | 200 µg/ml | $357.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 647 | sc-33710 AF647 | 200 µg/ml | $357.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 680 | sc-33710 AF680 | 200 µg/ml | $357.00 | |||
COL7A1 Antibody (4D2) Alexa Fluor® 790 | sc-33710 AF790 | 200 µg/ml | $357.00 |