COL18A1 Antibody (1837-46): sc-32720

COL18A1 Antibody (1837-46) is a mouse monoclonal IgG2b kappa light chain antibody that detects COL18A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Anti-COL18A1 antibody (1837-46) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COL18A1 plays a crucial role in the formation of the extracellular matrix and is involved in various biological processes, including tissue repair and angiogenesis. COL18A1 is primarily located in the basement membrane zones, where COL18A1 contributes to the structural integrity and function of tissues. COL18A1′s presence in these regions is vital for maintaining the interactions between the basement membrane and surrounding stromal cells, which is essential for proper tissue organization and function. COL18A1 produces endostatin, a fragment that inhibits angiogenesis and tumor growth, highlighting COL18A1′s importance in cancer biology and potential therapeutic applications. COL18A1′s unique structural features, including multiple triple-helical domains and non-collagenous regions, further underscore COL18A1′s significance in the diverse family of collagens, particularly within the MULTIPLEXIN subgroup, which includes Collagen Types XV and XVIII. COL18A1 monoclonal antibody (1837-46) is an invaluable tool for researchers studying COL18A1′s roles in various physiological and pathological processes.

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COL18A1 Antibody (1837-46) References:

1. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity.  |  Sasaki, T., et al. 2000. J Mol Biol. 301: 1179-90. PMID: 10966814
2. Genetic polymorphisms in COL18A1 influence the development of osteosarcoma.  |  Guo, Z., et al. 2015. Int J Clin Exp Pathol. 8: 11531-6. PMID: 26617886
3. Familial epilepsy with anterior polymicrogyria as a presentation of COL18A1 mutations.  |  Corbett, MA., et al. 2017. Eur J Med Genet. 60: 437-443. PMID: 28602933
4. Mutations in the COL18A1 gen associated with knobloch syndrome and structural brain anomalies: a novel case report and literature review of neuroimaging findings.  |  Irene Díez García-Prieto, I., et al. 2022. Neurocase. 28: 11-18. PMID: 35253627
5. Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis.  |  Liu, Y., et al. 2022. Cell Death Dis. 13: 578. PMID: 35787628
6. Generation of an induced pluripotent stem cell line (ZSZOCi001-A) from a patient with Knobloch syndrome caused by biallelic mutations in the gene COL18A1.  |  Jiang, Z., et al. 2023. Stem Cell Res. 70: 103131. PMID: 37269665
7. Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease.  |  Khoshneviszadeh, M., et al. 2024. Matrix Biol. 128: 39-64. PMID: 38387749
8. Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene.  |  Kivirikko, S., et al. 1994. J Biol Chem. 269: 4773-9. PMID: 8106446
9. Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21.  |  Oh, SP., et al. 1994. Genomics. 19: 494-9. PMID: 8188291
10. The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen.  |  Muragaki, Y., et al. 1994. J Biol Chem. 269: 4042-6. PMID: 8307960
11. Biochemical and immunohistochemical characterization of human type XIX defines a novel class of basement membrane zone collagens.  |  Myers, JC., et al. 1997. Am J Pathol. 151: 1729-40. PMID: 9403723
12. Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts.  |  Saarela, J., et al. 1998. Matrix Biol. 16: 319-28. PMID: 9503365

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL18A1 Antibody (1837-46) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-COL18A1 Antibody (1837-46) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL18A1 Antibody (1837-46) Specifications

Alternate Product Name: COL18A1

Product Clone Name: 1837-46

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Collagen Type XVIII

Epitope Species: mouse

Product Reactivity/Detection: Collagen Type XVIII

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for COL18A1 Antibody (1837-46): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin