COL10A1 Antibody (0.N.232): sc-70869

COL10A1 Antibody (0.N.232) is a mouse monoclonal IgG1 antibody that detects Collagen Type X in avian species through applications such as immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-COL10A1 antibody (0.N.232) is crucial for studying the role of Collagen Type X in the development and maintenance of hypertrophic chondrocytes within growth plate tissues, which are essential for the endochondral growth of long bones. COL10A1 (0.N.232) monoclonal antibody enables research of this protein as a key component of normal articular cartilage in various species, including humans, pigs, and newborn rats, while also supporting studies of its significant role in osteoarthritis pathology, where disruptions in metabolic status can lead to cartilage degradation. Structurally, Collagen Type X is composed of three identical alpha 1(X) chains that form a triple-helical region, which is vital for stability and function, flanked by a short N-terminal sequence and a larger non-collagenous C-terminal domain. The integrity of this structure is important for interaction with other extracellular matrix components, and mutations in the COL10A1 gene can lead to conditions such as metaphyseal dysplasia type Schmid, characterized by various skeletal deformities. Understanding the structure and function of Collagen Type X is essential for elucidating its role in both normal physiology and disease states, making COL10A1 (0.N.232) antibody a valuable tool for researchers in the field.

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COL10A1 Antibody (0.N.232) References:

1. Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.  |  Dong, YF., et al. 2006. J Cell Physiol. 208: 77-86. PMID: 16575901
2. Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells.  |  Fang, M., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 2601-8. PMID: 25341799
3. Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics.  |  Du, J., et al. 2015. BMC Genomics. 16: 792. PMID: 26470705
4. The pattern of duck sternal ossification and the changes of histological structure and gene expression therein.  |  Wang, Y., et al. 2021. Poult Sci. 100: 101112. PMID: 34116350
5. COL10A1 is a novel factor in the development of choroidal neovascularization.  |  Lv, D., et al. 2022. Microvasc Res. 139: 104239. PMID: 34520774
6. COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction.  |  Wen, Z., et al. 2022. Front Oncol. 12: 1049345. PMID: 36530986
7. Stat5a promotes Col10a1 gene expression during chondrocyte hypertrophic differentiation.  |  Wu, X., et al. 2023. Am J Transl Res. 15: 4006-4019. PMID: 37434818
8. COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma.  |  Xu, Q., et al. 2023. BMC Gastroenterol. 23: 397. PMID: 37974070
9. M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.  |  Qian, Y., et al. 2024. J Nanobiotechnology. 22: 72. PMID: 38374072
10. Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review).  |  Yi, Q., et al. 2024. Oncol Rep. 52: PMID: 39392043

The preferred COL10A1 antibody is COL10A1 Antibody (X-AC9): sc-59954.