Chk2 Antibody (DCS-273): sc-56297
- Chk2 Antibody (DCS-273) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length Chk2 of human origin
- recommended for detection of Chk2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Chk2 (A-11): sc-17747 for Chk2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Chk2 Antibody (DCS-273) for WB and IHC(P) applications. These reagents are now offered in bundles with Chk2 Antibody (DCS-273) (see ordering information below).
QUICK LINKS
Chk2 Antibody (DCS-273) is a mouse monoclonal IgG1 antibody that detects Chk2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Chk2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. Upon DNA damage, Chk2 is activated and phosphorylates Cdc25C, which inhibits phosphatase activity, thereby preventing the activation of cyclin-dependent kinases and blocking the progression of mitosis. This mechanism is vital for maintaining genomic stability, as cells can repair DNA before division, thus preventing the propagation of damaged DNA. Additionally, Chk2 interacts with various proteins involved in the DNA damage response, including p53, which is crucial for cell cycle regulation and apoptosis. The ability of Chk2 to modulate these interactions highlights its importance in cancer biology, where dysregulation of the DNA damage response can lead to tumorigenesis. Anti-Chk2 antibody (DCS-273) serves as an essential tool for researchers studying cell cycle regulation, DNA repair mechanisms, and the implications of these processes in cancer development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk2 Antibody (DCS-273) | sc-56297 | 200 µg/ml | $322.00 | |||
Chk2 Antibody (DCS-273): m-IgG Fc BP-HRP Bundle | sc-537098 | 200 µg Ab; 10 µg BP | $361.00 | |||
Chk2 Antibody (DCS-273): m-IgGκ BP-HRP Bundle | sc-534288 | 200 µg Ab; 40 µg BP | $361.00 | |||
Chk2 Antibody (DCS-273): m-IgG1 BP-HRP Bundle | sc-545002 | 200 µg Ab; 20 µg BP | $361.00 |