Chk1 Antibody (DCS-310): sc-56291
- Chk1 Antibody (DCS-310) is a mouse monoclonal IgG2b κ, cited in 43 publications, provided at 200 µg/ml
- raised against full length Chk1 of human origin
- Anti-Chk1 Antibody (DCS-310) is recommended for detection of Chk1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Chk1 Antibody (DCS-310) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for Chk1 Antibody (DCS-310) for WB and IHC(P) applications. These reagents are now offered in bundles with Chk1 Antibody (DCS-310) (see ordering information below).
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Chk1 Antibody (DCS-310) is a mouse monoclonal IgG2b kappa light chain antibody that detects Chk1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Chk1 antibody (DCS-310) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Chk1 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. By phosphorylating Cdc25C, Chk1 inhibits its activity, which in turn prevents the activation of cyclin-dependent kinases and blocks the progression of mitosis. This regulatory mechanism is vital for maintaining genomic stability, as cells can repair DNA damage before entering mitosis, thereby preventing the propagation of damaged DNA to daughter cells. Chk1 has been shown to interact with other proteins involved in cell cycle regulation, including Wee1, further underscoring Chk1′s importance in the intricate network of cell cycle control.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk1 Antibody (DCS-310) | sc-56291 | 200 µg/ml | $322.00 | |||
Chk1 Antibody (DCS-310): m-IgG Fc BP-HRP Bundle | sc-525652 | 200 µg Ab; 10 µg BP | $361.00 | |||
Chk1 Antibody (DCS-310): m-IgG2b BP-HRP Bundle | sc-549607 | 200 µg Ab; 10 µg BP | $361.00 | |||
Chk1 Antibody (DCS-310) AC | sc-56291 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Chk1 Antibody (DCS-310) HRP | sc-56291 HRP | 200 µg/ml | $322.00 | |||
Chk1 Antibody (DCS-310) FITC | sc-56291 FITC | 200 µg/ml | $336.00 | |||
Chk1 Antibody (DCS-310) PE | sc-56291 PE | 200 µg/ml | $349.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 488 | sc-56291 AF488 | 200 µg/ml | $364.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 546 | sc-56291 AF546 | 200 µg/ml | $364.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 594 | sc-56291 AF594 | 200 µg/ml | $364.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 647 | sc-56291 AF647 | 200 µg/ml | $364.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 680 | sc-56291 AF680 | 200 µg/ml | $364.00 | |||
Chk1 Antibody (DCS-310) Alexa Fluor® 790 | sc-56291 AF790 | 200 µg/ml | $364.00 |