cGKIα/β Antibody (G-3) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against amino acids 191-290 mapping within an internal region of cGKIα/β of human origin
Anti-cGKI alpha / beta Antibody (G-3) is recommended for detection of cGKIα/β of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-cGKI alpha / beta Antibody (G-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of cGKIα/β (G-3): sc-271766.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
cGKI (cGMP-dependent protein kinase type I), also known as PRKG1, lowers the intracellular level of calcium and is important for the relaxation of vascular smooth muscle. cGKI exists as two alternatively spliced isoforms, designated α and β, which differ only in their N-terminal sequence and function to catalyze the phosphorylation of target proteins. The cGKIα/β precursor contains one protein kinase domain, one AGC-kinase C-terminal domain and two cyclic nucleotide-binding domains. cGKII (cGMP-dependent protein kinase type II), a protein that is related to cGKI, is a major receptor of intracellular cGMP that mediates a plethora of physiological responses. cGKII contains a conserved leucine zipper motif at the amino terminus and is expressed in small intestine, colon, prostate and human brain tissue. cGKII has been shown to regulate the ion transport system in the intestine. Myristoylation of the penultimate glycine in cGKII appears to be essential for directing cGKII to the membrane, since cGKII is devoid of any hydrophobic transmembrane domains.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences