CES1 Antibody (B-4): sc-398236

CES1 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects CES1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CES1, a member of the type-B carboxylesterase/lipase family, plays a vital role in the detoxification processes within the liver, hydrolyzing a variety of xenobiotics and therapeutic pro-drugs, which is essential for drug metabolism and clearance. CES1 is primarily located in the cytosol of liver cells, where CES1 facilitates the breakdown of ester and amide compounds, including narcotics and anti-tumor agents. CES1 localization in the liver is particularly important as CES1 allows for efficient detoxification and metabolism of drugs before they enter systemic circulation, thereby influencing their therapeutic efficacy and safety. Additionally, CES1 exhibits a high affinity for aromatic and aliphatic esters, making CES1 a key player in the metabolism of various therapeutic agents. Anti-CES1 antibody (B-4) is an invaluable tool for researchers studying drug metabolism, liver function, and the pharmacokinetics of therapeutic compounds.

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CES1 Antibody (B-4) References:

1. Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.  |  Ferrero-Miliani, L., et al. 2017. Pharmacogenomics. 18: 1241-1257. PMID: 28786738
2. Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis.  |  Sychev, DA., et al. 2019. Mol Biol Rep. 46: 2761-2769. PMID: 30850966
3. Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention.  |  Saiz-Rodríguez, M., et al. 2019. Clin Ther. 41: 1199-1212.e2. PMID: 31128980
4. Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators.  |  Her, L. and Zhu, HJ. 2020. Drug Metab Dispos. 48: 230-244. PMID: 31871135
5. The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1.  |  Eisner, H., et al. 2022. Int J Mol Sci. 23: PMID: 36361897
6. The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillation.  |  Zhu, Z., et al. 2022. BMC Cardiovasc Disord. 22: 481. PMID: 36368930
7. The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613.  |  Ikonnikova, A., et al. 2022. Genes (Basel). 13: PMID: 36553492
8. Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway.  |  Ge, PX., et al. 2023. J Thromb Haemost. 21: 117-132. PMID: 36695375
9. The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC.  |  Abdrakhmanov, A., et al. 2023. Genes (Basel). 14: PMID: 37372371
10. Pyrazolone compounds could inhibit CES1 and ameliorates fat accumulation during adipocyte differentiation.  |  Wang, DD., et al. 2024. Bioorg Chem. 150: 107536. PMID: 38878751

The preferred CES1 antibody is CES1 Antibody (A-11): sc-365249.