CES1 Activators
CES1 Activators encompass a range of chemical compounds that augment CES1's functional activity through their interaction and metabolism by this enzyme. Benzbramarone, an agent utilized for its uricosuric properties, exemplifies this interaction by serving as a substrate that is preferentially hydrolyzed by CES1, thereby directly enhancing the enzyme's hydrolase activity on ester and amide bonds of various xenobiotics. This effect is mirrored in the metabolism of diltiazem, a calcium channel blocker, which upon being metabolized by CES1, escalates the enzyme's overall activity and capacity to process other substrates. Similarly, methylphenidate, a known psychostimulant, are metabolized by CES1, which not only engages but also accentuates the enzyme's activity, particularly in the hydrolysis of ester linkages. This mechanism is crucial in CES1's role in metabolism and the processing of various endogenous and exogenous esters.
Further expanding this array of activators, clopidogrel and oseltamivir are activated by CES1. This activation process enhances the enzymatic activity of CES1, facilitating its role in the hydrolysis of ester bonds in a variety of substrates. Anticoagulant rivaroxaban and antiarrhythmic agent quinidine, through their partial metabolism by CES1, lead to an increase in the enzyme's functional activity, underscoring its significance in drug metabolism and ester bond hydrolysis. Ticagrelor, an antiplatelet drug, and imatinib, a tyrosine kinase inhibitor, are transformed into their active forms by CES1, stimulating the enzyme's activity and enhancing its hydrolytic function on other ester-containing compounds. Lidocaine and atorvastatin, both substrates for CES1, further enhance the enzyme's capacity to hydrolyze ester bonds in various compounds. Collectively, these CES1 activators play a pivotal role in enhancing the enzyme's activity, particularly in metabolism and other compounds with ester bonds, showcasing the intricate interplay between CES1 and its substrates in physiological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzbromarone | 3562-84-3 | sc-233934 sc-233934A | 1 g 5 g | $53.00 $223.00 | ||
Benzbromarone, a uricosuric agent, enhances CES1 activity by being a substrate that is preferentially hydrolyzed. This interaction directly increases CES1's hydrolase activity on ester and amide bonds of various xenobiotics. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker, is metabolized by CES1, leading to its increased activity. The metabolism of diltiazem by CES1 increases the enzyme's activity on other substrates by upregulating its functional capacity. | ||||||
S-(+)-Clopidogrel Hydrogen Sulfate | 120202-66-6 | sc-220001 sc-220001A sc-220001B | 100 mg 1 g 5 g | $84.00 $168.00 $571.00 | 1 | |
Clopidogrel, an antiplatelet agent, is a prodrug activated by CES1. This activation process increases CES1’s enzymatic activity, facilitating its role in the hydrolysis of ester bonds in other substrates. | ||||||
Rivaroxaban | 366789-02-8 | sc-208311 | 2 mg | $158.00 | 18 | |
Rivaroxaban, an anticoagulant, undergoes partial metabolism by CES1. This interaction leads to an increase in CES1's functional activity, specifically in its role in drug metabolism and ester hydrolysis. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine, an antiarrhythmic agent, is metabolized by CES1. This metabolism enhances CES1's activity, particularly in the hydrolysis of other medicinal compounds with ester bonds. | ||||||
Ticagrelor | 274693-27-5 | sc-472972 sc-472972A sc-472972B sc-472972C | 10 mg 25 mg 50 mg 100 mg | $104.00 $228.00 $270.00 $302.00 | ||
Ticagrelor, an antiplatelet drug, is transformed into its active form by CES1. This process stimulates CES1's enzymatic activity, enhancing its hydrolytic function on other ester-containing drugs. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib, a tyrosine kinase inhibitor, is partially metabolized by CES1. This metabolism enhances CES1's activity, increasing its efficacy in hydrolyzing ester bonds in various substrates. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine, a local anesthetic, is a substrate for CES1. Its metabolism by CES1 not only engages but also enhances the enzyme's capacity to hydrolyze ester bonds in other compounds. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Atorvastatin, a cholesterol-lowering drug, undergoes hydrolysis by CES1. This interaction boosts CES1's hydrolase activity, particularly in the metabolism of other drugs with similar ester linkages. | ||||||