Centaurin γ3 Antibody (A-10): sc-393553
- Centaurin γ3 Antibody (A-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 826-875 mapping at the C-terminus of Centaurin γ3 of human origin
- recommended for detection of Centaurin γ3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Centaurin γ3 Antibody (A-10) for WB applications. These reagents are now offered in bundles with Centaurin γ3 Antibody (A-10) (see ordering information below).
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Centaurin γ3 Antibody (A-10) is a mouse monoclonal IgG2a antibody that detects Centaurin γ3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Centaurin γ3 is a member of the Centaurin GTPase-activating protein family, which plays a crucial role in regulating ADP-ribosylation factor (ARF) proteins, particularly in vesicular transport and cytoskeletal organization. Centaurin γ3 is primarily located in the cytoplasm and shows high affinity for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), which is essential for cellular signaling pathways. Centaurin γ3 interaction with PtdIns(3,4,5)P3 is vital for modulating ARF6 activity, acting as a GTPase-activating protein that switches off ARF6, thereby inhibiting processes such as β2-adrenoceptor internalization. This regulatory mechanism maintains cellular homeostasis and ensures proper membrane trafficking, making Centaurin γ3 significant in various physiological processes. Through interactions with key signaling lipids and proteins, Centaurin γ3 serves as an important target for research into cellular dynamics and mechanisms of diseases related to vesicular transport dysfunction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Centaurin γ3 Antibody (A-10) | sc-393553 | 200 µg/ml | $322.00 | |||
Centaurin γ3 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-538246 | 200 µg Ab; 10 µg BP | $361.00 | |||
Centaurin γ3 Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-535821 | 200 µg Ab; 40 µg BP | $361.00 | |||
Centaurin γ3 Antibody (A-10): m-IgG2a BP-HRP Bundle | sc-548247 | 200 µg Ab; 10 µg BP | $361.00 |