Centaurin γ3 Antibody (E-8): sc-271793

Centaurin γ3 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Centaurin gamma 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Centaurin γ3 antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Centaurin gamma 3 plays a crucial role in regulating vesicular transport and cytoskeletal organization, which are essential for maintaining cellular structure and function. This protein belongs to the ADP-ribosylation factor (ARF) family of small GTP-binding proteins, which regulate membrane traffic. Centaurin gamma 3 transduces phosphoinositide 3-kinase activation into the control of ARF-dependent pathways, influencing processes such as cell adhesion and migration. Centaurin gamma 3 interacts with other members of the Centaurin GTPase-activating protein family, including ASAP1 and ACAP1, highlighting its importance in cellular signaling and transport mechanisms. Centaurin γ3 (E-8) monoclonal antibody enables researchers to gain valuable insights into the functional dynamics of Centaurin gamma 3 and its implications in various biological processes.

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Centaurin γ3 Antibody (E-8) References:

1. Cytohesins and centaurins control subcellular trafficking of macromolecular signaling complexes: regulation by phosphoinositides and ADP-ribosylation factors.  |  Hawadle, MA., et al. 2002. Biol Res. 35: 247-65. PMID: 12415743
2. Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization.  |  Venkateswarlu, K., et al. 2004. J Biol Chem. 279: 6205-8. PMID: 14625293
3. The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.  |  Thacker, E., et al. 2004. Eur J Cell Biol. 83: 541-54. PMID: 15679100
4. Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.  |  Lawrence, J., et al. 2005. Mol Pharmacol. 67: 1822-8. PMID: 15778454
5. Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B.  |  Venkateswarlu, K., et al. 2005. J Cell Sci. 118: 2471-84. PMID: 15923660
6. Centaurin-alpha1 and KIF13B kinesin motor protein interaction in ARF6 signalling.  |  Kanamarlapudi, V. 2005. Biochem Soc Trans. 33: 1279-81. PMID: 16246098
7. Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases.  |  Hayashi, H., et al. 2006. J Biol Chem. 281: 1332-7. PMID: 16287813
8. Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.  |  Nagashima, S., et al. 2019. Sci Rep. 9: 20107. PMID: 31882856
9. Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice.  |  Nagashima, S., et al. 2021. J Biol Chem. 296: 100620. PMID: 33811862
10. AGAP3: A novel BRAF fusion partner in pediatric pancreatic-type acinar cell carcinoma.  |  Paoli, C., et al. 2022. Genes Chromosomes Cancer. 61: 734-739. PMID: 35949061
11. Whole transcriptome sequencing reveals HOXD11-AGAP3, a novel fusion transcript in the Indian acute leukemia cohort.  |  Desai, SS., et al. 2023. Front Genet. 14: 1100587. PMID: 37113989
12. Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.  |  Højgaard, K., et al. 2023. Mol Brain. 16: 69. PMID: 37749596

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Centaurin γ3 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Centaurin γ3 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Centaurin γ3 Antibody (E-8) Specifications

Alternate Product Name: Centaurin γ3

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 849-874

Epitope Target: Centaurin γ3

Epitope Species: human

Product Reactivity/Detection: Centaurin γ3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Centaurin γ3 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin