Cdx2 Antibody (E-1): sc-393572

Cdx2 Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Cdx2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Cdx2 antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cdx2 plays a crucial role in regulating intestinal development and differentiation, acting as a transcription factor that influences gene expression necessary for maintaining intestinal phenotype. Cdx2 (E-1) monoclonal antibody is essential for studying proper patterning of intestinal epithelium, as Cdx2 helps establish anterior-posterior axis during embryonic development. Cdx2 expression is vital for proliferation and differentiation of intestinal cells, and decreased Cdx2 levels have been linked to colorectal cancer progression. The interplay between Cdx1 and Cdx2 maintains normal intestinal function and reduces tumorigenic potential. anti-Cdx2 antibody (E-1) serves as a valuable tool for researchers studying intestinal biology and cancer, providing insights into mechanisms of intestinal development and potential pathways involved in tumorigenesis.

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Cdx2 Antibody (E-1) References:

1. Cdx1 and cdx2 expression during intestinal development.  |  Silberg, DG., et al. 2000. Gastroenterology. 119: 961-71. PMID: 11040183
2. Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I.  |  Moucadel, V., et al. 2001. Eur J Cell Biol. 80: 156-63. PMID: 11302520
3. Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells.  |  Soubeyran, P., et al. 2001. Oncogene. 20: 4180-7. PMID: 11464284
4. The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells.  |  Oh, EJ., et al. 2002. Int J Oncol. 20: 23-9. PMID: 11743638
5. Multiple pathways governing Cdx1 expression during murine development.  |  Prinos, P., et al. 2001. Dev Biol. 239: 257-69. PMID: 11784033
6. RARgamma and Cdx1 interactions in vertebral patterning.  |  Allan, D., et al. 2001. Dev Biol. 240: 46-60. PMID: 11784046
7. The role of Cdx2 in Barrett's metaplasia.  |  Colleypriest, BJ., et al. 2010. Biochem Soc Trans. 38: 364-9. PMID: 20298184
8. Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.  |  Tilson, MP., et al. 2014. Head Neck Pathol. 8: 59-65. PMID: 23846317
9. Cdx2 Animal Models Reveal Developmental Origins of Cancers.  |  Chawengsaksophak, K. 2019. Genes (Basel). 10: PMID: 31739541
10. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene.  |  Bonner, CA., et al. 1995. Genomics. 28: 206-11. PMID: 8530027
11. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.  |  Mallo, GV., et al. 1997. Int J Cancer. 74: 35-44. PMID: 9036867
12. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells.  |  Mallo, GV., et al. 1998. J Biol Chem. 273: 14030-6. PMID: 9593754

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdx2 Antibody (E-1) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdx2 Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdx2 Antibody (E-1) Specifications

Alternate Product Name: Cdx2

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 261-292

Epitope Target: Cdx2

Epitope Species: human

Product Reactivity/Detection: Cdx2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Cdx2 Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin