CD3-ζ Antibody (E-3): sc-166435
- CD3-ζ Antibody (E-3) is a mouse monoclonal IgG3 κ, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 137-163 at the C-terminus of CD3-ζ of human origin
- recommended for detection of CD3-ζ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- See CD3-ζ (6B10.2): sc-1239 for CD3-ζ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for CD3-ζ Antibody (E-3) for WB applications. This reagent is now offered in a bundle with CD3-ζ Antibody (E-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
CD3-ζ Antibody (E-3) is a mouse monoclonal IgG3 kappa light chain antibody that detects CD3-ζ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD3-ζ (E-3) antibody is available in a non-conjugated form, specifically designed for CD3-ζ detection. CD3-ζ plays a crucial role in T cell activation as a key component of the T cell receptor (TCR) complex, which is essential for recognizing foreign antigens. Upon antigen recognition, the TCR complex transmits signals that lead to T cell activation, proliferation, and differentiation, making CD3-ζ vital for the adaptive immune response. The structure of CD3-ζ is particularly important because CD3-ζ contains three immunoreceptor tyrosine-based activation motifs (ITAMs) that are critical for initiating signaling cascades upon TCR engagement. These ITAMs serve as docking sites for various protein kinases, including ZAP-70, which further propagate the activation signal within the T cell. The unique arrangement of ITAMs in CD3-ζ enhances signaling response amplification, ensuring a robust immune reaction. Understanding CD3-ζ function and structure is essential for developing therapeutic strategies aimed at modulating T cell responses in various diseases, including cancer and autoimmune disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD3-ζ Antibody (E-3) | sc-166435 | 200 µg/ml | $322.00 | |||
CD3-ζ Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-521608 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD3-ζ (E-3) Neutralizing Peptide | sc-166435 P | 100 µg/0.5 ml | $69.00 |