CD206/Mannose Receptor/MMR Antibody (15-2): sc-58986

CD206 Antibody (15-2) is a mouse monoclonal IgG1 kappa light chain antibody raised against CD206 of human origin, detecting CD206 from mouse, rat, and human origins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD206, also known as the Mannose Receptor (MR), Macrophage Mannose Receptor (MMR), or Mannose Receptor C Type 1 (MRC1), is a type I membrane receptor protein primarily expressed on macrophages, immature dendritic cells, hepatic and lymphatic endothelial cells, retinal pigment epithelium (RPE), and mesangial cells. CD206 functions as a phagocytic and endocytic receptor that recognizes carbohydrate ligands on the surface of pathogens, facilitating their uptake and clearance by the immune system. The extracellular portion of CD206 includes eight C-type carbohydrate recognition domains (CRDs), which cluster together to achieve high-affinity binding to mannose, fucose, and N-acetylglucosamine residues present on bacteria, fungi, and viruses. By mediating the endocytosis of glycoproteins and enabling phagocytic engulfment of pathogens, CD206 plays a crucial role in innate immunity and the rapid clearance of mannose-bearing serum glycoproteins during inflammation. Understanding CD206 function is important for research into immune responses, pathogen recognition, and potential therapeutic interventions targeting macrophage activity. Anti-CD206 antibody (15-2) offers a valuable tool for researchers to detect and study CD206 expression across multiple species, enhancing the advancement of immunological studies and therapeutic developments.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD206/Mannose Receptor/MMR Antibody (15-2) has 79 citations in a variety of scientific publications.

Primary antibodies like Anti-CD206/Mannose Receptor/MMR Antibody (15-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD206/Mannose Receptor/MMR Antibody (15-2) Specifications

Alternate Product Name: MRC1

Product Clone Name: 15-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD206

Epitope Species: human

Product Reactivity/Detection: CD206

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 79 citations in various scientific publications

Available Conjugates/Forms for CD206/Mannose Receptor/MMR Antibody (15-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CD206/Mannose Receptor/MMR antibody is CD206/Mannose Receptor/MMR Antibody (D-1): sc-376108.