CD206 Activators
The term CD206 activators refers to a class of chemicals that intricately modulate the activity of CD206, a C-type lectin receptor predominantly expressed on macrophages and closely associated with the anti-inflammatory M2 macrophage polarization phenotype. CD206, also known as the mannose receptor, stands as a key player in immune regulation, tissue repair, and homeostasis. While the identification of direct activators for CD206 remains limited, a spectrum of chemicals has been recognized for their indirect influence on its expression, primarily through the modulation of signaling pathways associated with macrophage polarization and inflammation. Dexamethasone, a synthetic glucocorticoid, emerges as a noteworthy CD206 modulator. Its mode of action involves the inhibition of NF-κB signaling, a pivotal pathway in inflammation. By attenuating pro-inflammatory signals, dexamethasone facilitates the expression of CD206 on macrophages, thereby contributing to the induction of an anti-inflammatory M2 macrophage phenotype. This modulation is integral to the resolution of inflammation and the promotion of tissue homeostasis.
Macrophage colony-stimulating factor (M-CSF), a key regulator of macrophage differentiation, also operates as an indirect CD206 influencer. M-CSF plays a critical role in stimulating monocyte differentiation into M2 macrophages, a process associated with increased CD206 expression. The induction of an M2 phenotype through M-CSF contributes to anti-inflammatory responses, showcasing its role in shaping the immune microenvironment. Peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists, exemplified by Rosiglitazone, constitute another category of CD206 modulators. Through the activation of PPAR-γ, these agonists promote M2 macrophage polarization, leading to an upregulation of CD206 expression. Rosiglitazone, as an example, exemplifies how PPAR-γ agonists can dynamically shift macrophages towards an anti-inflammatory phenotype, thereby modulating CD206 expression and contributing to immune regulatory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid that indirectly activates CD206 by modulating the NF-κB pathway. Dexamethasone inhibits NF-κB activation, reducing pro-inflammatory signals and promoting the expression of CD206 on macrophages, contributing to anti-inflammatory responses. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A peroxisome proliferator-activated receptor-gamma agonist that indirectly activates CD206. Rosiglitazone activates PPAR-γ, promoting the transcription of CD206 and shifting macrophages towards an anti-inflammatory M2 phenotype. This contributes to tissue homeostasis and resolution of inflammation. | ||||||
Polymyxin B Sulfate | 1405-20-5 | sc-3544 | 500 mg | $63.00 | 8 | |
An antibiotic that indirectly influences CD206 by inhibiting LPS-induced inflammation. Polymyxin B binds to and neutralizes LPS, preventing its interaction with macrophages and reducing pro-inflammatory signals. This indirectly supports the expression of CD206 on macrophages and promotes an anti-inflammatory state. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that indirectly activates CD206 by modulating NF-κB and STAT signaling. Resveratrol inhibits NF-κB activation and enhances STAT6 signaling, leading to increased CD206 expression on macrophages. This dual modulation contributes to the anti-inflammatory and tissue-protective effects of resveratrol. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that indirectly activates CD206 by influencing macrophage polarization. Rapamycin inhibits mTOR signaling, promoting the M2 macrophage phenotype, which is associated with increased CD206 expression. This contributes to the anti-inflammatory and tissue repair properties of rapamycin. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
A fat-soluble vitamin that indirectly activates CD206 through VDR signaling. Vitamin D3 binds to the vitamin D receptor (VDR), leading to the transcriptional activation of CD206 and promoting the M2 macrophage phenotype. This contributes to the anti-inflammatory effects of vitamin D3 in macrophage modulation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
A lipid mediator that indirectly activates CD206 by modulating cAMP-PKA signaling. PGE2 activates the EP2/EP4 receptors, leading to increased cAMP levels and PKA activation. This enhances CD206 expression on macrophages, promoting the M2 phenotype and contributing to the anti-inflammatory effects of PGE2. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
A bioactive lipid that indirectly activates CD206 by influencing macrophage polarization. S1P promotes the M2 macrophage phenotype, leading to increased CD206 expression. This contributes to the anti-inflammatory and tissue repair properties associated with S1P signaling in macrophages. | ||||||