CD100 Antibody (D-5): sc-166367

CD100 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects CD100 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD100, also known as SEMA4D, is a transmembrane protein that plays a crucial role in the immune system, being the only member of the semaphorin family expressed in immune tissues. CD100 is vital for T cell proliferation and B cell aggregation, as CD100 regulates B cell responses by counteracting inhibitory signals from CD72, which typically suppresses B cell activity. When CD100 binds to CD72, CD100 induces tyrosine dephosphorylation of CD72, leading to the dissociation of SHP-1, a negative regulator of B cell signaling. CD100 expression is observed in various tissues, including the kidney, heart, lung, and neural tissues, highlighting CD100′s importance in both embryonic and adult development. The gene encoding human CD100 is located on chromosome 9q22-q31, and CD100′s interactions with receptors like Plexin-B1, which is predominantly found in fetal brain and kidney, further underscore CD100′s significance in cellular communication and immune responses. Anti-CD100 antibody (D-5) is an essential tool for researchers studying immune regulation and the intricate signaling pathways involved in B cell activation and proliferation.

The preferred CD100 antibody is CD100 Antibody (C-3): sc-390675.