CBS Antibody (G-1): sc-271886
- CBS Antibody (G-1) is a mouse monoclonal IgG2a κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 179-199 within an internal region of CBS of human origin
- recommended for detection of CBS of mouse, rat and human origin by WB, IP, IF and ELISA
- See CBS (B-4): sc-133154 for CBS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CBS Antibody (G-1) for WB applications. These reagents are now offered in bundles with CBS Antibody (G-1) (see ordering information below).
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SEE ALSO...
CBS Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects cystathionine b-synthase (CBS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CBS is a crucial cytoplasmic protein predominantly expressed in the human liver and pancreas, with lower levels found in the heart and brain, where CBS plays a vital role in the transsulfuration pathway by catalyzing the conversion of homocysteine, a potentially harmful amino acid, into cystathionine using pyridoxal phosphate as a cofactor. This enzymatic reaction is essential for maintaining proper levels of homocysteine in the body, as elevated homocysteine is associated with various cardiovascular diseases and neurological disorders. The activity of CBS is allosterically regulated by adenosyl-methionine, highlighting the importance of metabolic control in preventing the detrimental effects of homocysteine accumulation. Deficiencies in CBS can lead to homocystinuria, a genetic disorder characterized by a range of serious symptoms, including arteriosclerosis, thrombosis, dislocated optic lenses, cognitive impairments, and skeletal abnormalities, underscoring CBS′s critical role in sulfur amino acid metabolism and overall health. Anti-CBS antibody (G-1) is an invaluable tool for researchers studying these pathways and their implications in disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBS Antibody (G-1) | sc-271886 | 200 µg/ml | $322.00 | |||
CBS Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-537706 | 200 µg Ab; 10 µg BP | $361.00 | |||
CBS Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-535058 | 200 µg Ab; 40 µg BP | $361.00 | |||
CBS (G-1) Neutralizing Peptide | sc-271886 P | 100 µg/0.5 ml | $69.00 |