CBS Antibody (G-1): sc-271886

CBS Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects cystathionine b-synthase (CBS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CBS is a crucial cytoplasmic protein predominantly expressed in the human liver and pancreas, with lower levels found in the heart and brain, where CBS plays a vital role in the transsulfuration pathway by catalyzing the conversion of homocysteine, a potentially harmful amino acid, into cystathionine using pyridoxal phosphate as a cofactor. This enzymatic reaction is essential for maintaining proper levels of homocysteine in the body, as elevated homocysteine is associated with various cardiovascular diseases and neurological disorders. The activity of CBS is allosterically regulated by adenosyl-methionine, highlighting the importance of metabolic control in preventing the detrimental effects of homocysteine accumulation. Deficiencies in CBS can lead to homocystinuria, a genetic disorder characterized by a range of serious symptoms, including arteriosclerosis, thrombosis, dislocated optic lenses, cognitive impairments, and skeletal abnormalities, underscoring CBS′s critical role in sulfur amino acid metabolism and overall health. Anti-CBS antibody (G-1) is an invaluable tool for researchers studying these pathways and their implications in disease.

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CBS Antibody (G-1) References:

1. The association of cystathionine β synthase (CBS) T833C polymorphism and the risk of stroke: a meta-analysis.  |  Ding, R., et al. 2012. J Neurol Sci. 312: 26-30. PMID: 21917271
2. Endogenous CBS-H2S Pathway Contributes to the Development of CCI-Induced Neuropathic Pain.  |  Gui, Y., et al. 2016. Neurochem Res. 41: 1381-9. PMID: 26961888
3. Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis.  |  Qi, QR., et al. 2020. Endocrinology. 161: PMID: 32987401
4. CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.  |  Cai, S., et al. 2021. Cell Prolif. 54: e12950. PMID: 33179842
5. Low CBS expression can identify patients who benefit from adjuvant chemotherapy in gastric cancer.  |  Zhao, J., et al. 2021. Expert Rev Anticancer Ther. 21: 1287-1298. PMID: 34320879
6. Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia.  |  Nakladal, D., et al. 2022. FASEB J. 36: e22260. PMID: 35315960
7. Total flavones of Rhododendron induce the transformation of A1/A2 astrocytes via promoting the release of CBS-produced H2S.  |  Yin, X., et al. 2023. Phytomedicine. 111: 154666. PMID: 36701996
8. Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet.  |  Lambooy, S., et al. 2023. Int J Mol Sci. 24: PMID: 37108182
9. Application of Oxazaborolidine Catalysts (CBS) on Enantioselective 1,4-Addition of Diarylphosphine Oxides to α,β-Unsaturated Thioesters.  |  Shi, Y., et al. 2023. Org Lett. 25: 6495-6500. PMID: 37646432
10. Acute pancreatitis as a key to diagnosis of hyperhomocysteinemia in a 12-year-old boy caused by CBS gene mutation.  |  Wang, S., et al. 2023. Lancet. 402: 2235-2236. PMID: 38070950

The preferred CBS antibody is CBS Antibody (B-4): sc-133154.