CBS Antibody (A-2): sc-133208
- CBS Antibody (A-2) is a mouse monoclonal IgG2b κ, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 101-400 mapping within an internal region of CBS of human origin
- recommended for detection of CBS of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CBS (B-4): sc-133154 for CBS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for CBS Antibody (A-2) for WB and IHC(P) applications. These reagents are now offered in bundles with CBS Antibody (A-2) (see ordering information below).
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SEE ALSO...
CBS Antibody (A-2) is a mouse monoclonal IgG2b antibody that detects cystathionine b-synthase (CBS) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CBS is a crucial cytoplasmic protein predominantly expressed in the human liver and pancreas, with lower levels found in the heart and brain, and CBS plays a vital role in the first step of homocysteine transulfuration, catalyzing the conversion of homocysteine into cystathionine using pyridoxal phosphate as a cofactor. The regulation of CBS activity is significantly influenced by allosteric activation from adenosyl-methionine, which is essential for maintaining proper metabolic function. Deficiencies in CBS can lead to homocystinuria, a genetic disorder characterized by a disruption in sulfur amino acid metabolism that can have severe consequences for multiple organ systems. Symptoms of this condition include arteriosclerosis, thrombosis, dislocated optic lenses, cognitive impairments, and skeletal abnormalities, highlighting the importance of CBS in overall health and metabolic balance. Anti-CBS antibody (A-2) is an invaluable tool for researchers studying the implications of CBS in metabolic disorders and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBS Antibody (A-2) | sc-133208 | 200 µg/ml | $322.00 | |||
CBS Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-539867 | 200 µg Ab; 10 µg BP | $361.00 | |||
CBS Antibody (A-2): m-IgG2b BP-HRP Bundle | sc-549754 | 200 µg Ab; 10 µg BP | $361.00 |