Cbl-3 Antibody (G-6): sc-390649

Cbl-3 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects Cbl-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cbl-3, also known as RING finger protein 57, plays a crucial role in cellular signaling pathways by functioning as an E3 ubiquitin ligase, which is essential for the ubiquitination process that regulates protein degradation and turnover. This regulation is vital for maintaining cellular homeostasis and controlling various biological processes, including cell cycle progression and apoptosis. Cbl-3 is primarily located in the cytoplasm, where Cbl-3 interacts with other signaling proteins to modulate their activity, thereby influencing critical cellular responses. Notably, Cbl-3 is part of a larger family of Cbl proteins, which includes Cbl and Cbl-b, and these proteins are known to be involved in the regulation of receptor tyrosine kinases and other signaling molecules, making them significant in the context of cancer biology and therapeutic interventions. Anti-Cbl-3 antibody (G-6) is an invaluable tool for researchers studying the intricate mechanisms of signal transduction and the implications of Cbl proteins in various diseases, particularly in hematological malignancies where aberrant signaling pathways are often implicated.

The preferred Cbl-3 antibody is Cbl-3 Antibody (F-2): sc-390648.