caspase-7 p20 Antibody (C-12): sc-133248

Caspase-7 p20 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects caspase-7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Caspase-7 is a crucial member of the Ced-3/caspase-1 family of cysteine proteases, which are integral to the apoptotic process, facilitating programmed cell death by cleaving specific substrates vital for cellular homeostasis. Notably, caspase-7 cleaves poly(ADP-ribose) polymerase (PARP), a key protein involved in DNA repair and cellular stress responses, into an apoptotic fragment, thereby promoting apoptosis in response to cellular damage. Caspase-7 activation occurs downstream of caspase-3, highlighting a role in the execution phase of apoptosis. Caspase-7 interacts with various proteins, including caspase-6 and caspase-9, which further underscores an importance in the apoptotic signaling cascade. Caspase-7′s ability to modulate cellular responses to stress and damage makes this protein a significant target for research in cancer and neurodegenerative diseases, where dysregulation of apoptosis is a common feature.

The preferred caspase-7 antibody is caspase-7 Antibody (10-1-62): sc-56063.