caspase-5 p20 Antibody (H-2): sc-393346

Caspase-5 p20 Antibody (H-2) is a mouse monoclonal IgM antibody that detects caspase-5 p20 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-caspase-5 p20 antibody (H-2) is available as the non-conjugated form. Caspases, including caspase-5, are crucial cysteine proteases involved in the regulation of apoptosis and the activation of inflammatory cytokines. Specifically, caspase-5 is known to play a significant role in the inflammatory response by cleaving pro-inflammatory cytokines, thereby facilitating their maturation and release. This function is particularly important in the context of immune responses and tissue homeostasis, as dysregulation of caspase activity can lead to various pathological conditions, including cancer and autoimmune diseases. The human caspase 5 gene is located on chromosome 11q22.3 and is predominantly expressed in the brain, with notable levels in the lung, liver, and skeletal muscle, highlighting its potential involvement in both central and peripheral immune responses. Additionally, frameshift mutations in caspase-5 have been identified in various tumors, suggesting a role as a novel target gene within the microsatellite mutator pathway in cancer research.

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caspase-5 p20 Antibody (H-2) References:

1. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.  |  Schwartz, S., et al. 1999. Cancer Res. 59: 2995-3002. PMID: 10383166
2. Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides.  |  Taylor, S., et al. 2000. DNA Seq. 10: 387-94. PMID: 10826695
3. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.  |  Martinon, F., et al. 2002. Mol Cell. 10: 417-26. PMID: 12191486
4. Interaction between caspase-3 and caspase-5 in the stretch-induced programmed cell death in the human periodontal ligament cells.  |  Wu, Y., et al. 2019. J Cell Physiol. 234: 13571-13581. PMID: 30604868
5. Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death.  |  Bolívar, BE., et al. 2021. J Immunol. 206: 1878-1889. PMID: 33741688
6. SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade.  |  Wang, X., et al. 2021. EMBO J. 40: e108080. PMID: 34747049
7. The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage.  |  Ghait, M., et al. 2023. Front Immunol. 14: 1239474. PMID: 38106412
8. Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection.  |  Rooney, M., et al. 2024. J Hepatol. 81: 971-982. PMID: 38936554
9. Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.  |  Munday, NA., et al. 1995. J Biol Chem. 270: 15870-6. PMID: 7797592
10. Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme.  |  Faucheu, C., et al. 1996. Eur J Biochem. 236: 207-13. PMID: 8617266
11. Characterization of seven murine caspase family members.  |  Van de Craen, M., et al. 1997. FEBS Lett. 403: 61-9. PMID: 9038361
12. Caspases: the executioners of apoptosis.  |  Cohen, GM. 1997. Biochem J. 326 (Pt 1): 1-16. PMID: 9337844

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-5 p20 Antibody (H-2) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-5 p20 Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-5 p20 Antibody (H-2) Specifications

Alternate Product Name: caspase-5 p20

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 120-153

Epitope Target: caspase-5 p20

Epitope Species: human

Product Reactivity/Detection: caspase-5 precursor and p20 subunit

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for caspase-5 p20 Antibody (H-2): P: Blocking Peptide