caspase-4 Antibody (4B9): sc-56056

Caspase-4 Antibody (4B9) is a mouse monoclonal IgG1 antibody that detects caspase-4 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-caspase-4 antibody (4B9) is available as a non-conjugated format. Caspase-4 is a member of the Ced-3/caspase-1 family of cysteine proteases, which are crucial for executing apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and eliminating damaged cells. This family includes other well-known caspases such as caspase-1, caspase-3, and caspase-9, each playing distinct roles in apoptotic signaling pathways. Notably, caspase-4 is involved in inflammatory response and has been implicated in activating inflammatory caspases, which can lead to pro-inflammatory cytokine release. Proper functioning of caspase-4 is vital, as dysregulation can contribute to various diseases, including neurodegenerative disorders and cancer. Understanding caspase-4 interactions and regulatory mechanisms can provide insights into therapeutic targets for these conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

caspase-4 Antibody (4B9) References:

1. Caspase-4/11-Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension.  |  Wu, Y., et al. 2022. Hypertension. 79: 536-548. PMID: 34984912
2. Structural insights into cytokine cleavage by inflammatory caspase-4.  |  Devant, P., et al. 2023. Nature. 624: 451-459. PMID: 37993712
3. Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.  |  Shi, X., et al. 2023. Nature. 624: 442-450. PMID: 37993714
4. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.  |  Lindahl, T., et al. 1995. Trends Biochem Sci. 20: 405-11. PMID: 8533153
5. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
6. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.  |  Casciola-Rosen, L., et al. 1996. J Exp Med. 183: 1957-64. PMID: 8642305
7. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
8. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
9. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
10. The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex.  |  Simbulan-Rosenthal, CM., et al. 1996. Biochemistry. 35: 11622-33. PMID: 8794742
11. Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.  |  Kamada, S., et al. 1997. Oncogene. 15: 285-90. PMID: 9233763
12. Caspase-14 is a novel developmentally regulated protease.  |  Hu, S., et al. 1998. J Biol Chem. 273: 29648-53. PMID: 9792675

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-4 Antibody (4B9) has 36 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-4 Antibody (4B9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-4 Antibody (4B9) Specifications

Alternate Product Name: caspase-4

Product Clone Name: 4B9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1-270

Epitope Target: caspase-4

Epitope Species: human

Product Reactivity/Detection: caspase-4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 36 citations in various scientific publications

Available Conjugates/Forms for caspase-4 Antibody (4B9): N/A