caspase-14 p10 Antibody (B-3): sc-515259

caspase-14 p10 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects caspase-14 p10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-caspase-14 p10 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Caspase-14, also known as MICE (mini-ICE), plays a crucial role in the apoptotic process, particularly during embryonic development, where caspase-14 is highly expressed. Caspase-14 is unique among the caspase family due to specific processing and activation pathways; procaspase-14 can be cleaved by caspase-8 and caspase-10, but not by other caspases, highlighting a specialized function in apoptosis. The p10 subunit of caspase-14 is essential for enzymatic activity, allowing selective targeting and cleaving of specific substrates vital for regulating cell death and survival. Understanding caspase-14 function is important, as dysregulation of apoptosis can lead to various diseases, including cancer and neurodegenerative disorders.

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caspase-14 p10 Antibody (B-3) References:

1. Identification of a new caspase homologue: caspase-14.  |  Van de Craen, M., et al. 1998. Cell Death Differ. 5: 838-46. PMID: 10203698
2. Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator.  |  Chew, J., et al. 2010. J Cell Biochem. 111: 1359-66. PMID: 20830735
3. Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.  |  Øverbye, A., et al. 2011. Autophagy. 7: 1011-27. PMID: 21610319
4. Two aspartate residues at the putative p10 subunit of a type II metacaspase from Nicotiana tabacum L. may contribute to the substrate-binding pocket.  |  Acosta-Maspons, A., et al. 2014. Planta. 239: 147-60. PMID: 24121807
5. Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10.  |  de Melo, FM., et al. 2015. Immunol Cell Biol. 93: 86-98. PMID: 25223833
6. Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.  |  Li, M., et al. 2018. Cell Death Dis. 9: 516. PMID: 29725008
7. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.  |  Duan, H., et al. 1996. J Biol Chem. 271: 1621-5. PMID: 8576161
8. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.  |  Casciola-Rosen, L., et al. 1996. J Exp Med. 183: 1957-64. PMID: 8642305
9. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.  |  Duan, H., et al. 1996. J Biol Chem. 271: 16720-4. PMID: 8663294
10. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.  |  Fernandes-Alnemri, T., et al. 1996. Proc Natl Acad Sci U S A. 93: 7464-9. PMID: 8755496
11. Caspase-14 is a novel developmentally regulated protease.  |  Hu, S., et al. 1998. J Biol Chem. 273: 29648-53. PMID: 9792675
12. Identification and characterization of murine caspase-14, a new member of the caspase family.  |  Ahmad, M., et al. 1998. Cancer Res. 58: 5201-5. PMID: 9823333

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caspase-14 p10 Antibody (B-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-caspase-14 p10 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caspase-14 p10 Antibody (B-3) Specifications

Alternate Product Name: caspase-14 p10

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 236-257

Epitope Target: caspase-14 p10

Epitope Species: mouse

Product Reactivity/Detection: the p10 subunit and precursor of caspase-14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for caspase-14 p10 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred caspase-14 antibody is caspase-14 Antibody (D-10): sc-48336.