caspase-1 Antibody (D-3): sc-392736
- caspase-1 Antibody (D-3) is a mouse monoclonal IgG1 κ caspase-1 antibody, cited in 66 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 367-391 near the C-terminus of caspase-1 of human origin
- caspase-1 Antibody (D-3) is recommended for detection of caspase-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-caspase-1 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-1 Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with caspase-1 Antibody (D-3) (see ordering information below).
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SEE ALSO...
caspase-1 Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect caspase-1, also known as IL-1 converting enzyme (ICE), across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). caspase-1 monoclonal antibody (D-3) targets a unique epitope spanning amino acids 367-391 near the C-terminus of human caspase-1, ensuring precise recognition of both the precursor and active forms of the protein in mouse, rat, and human samples. Caspase-1 is a pivotal protease involved in the inflammatory response and apoptosis, playing a crucial role in the maturation of pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) through the proteolytic cleavage of their inactive precursors. Post-translational modifications of caspase-1, particularly autocatalytic cleavage into the p20 and p10 subunits, are essential for activation and subsequent enzymatic activity, which drives inflammatory signaling and programmed cell death. The structural integrity and regulation of caspase-1 through these modifications are vital for maintaining cellular homeostasis and responding to pathological stimuli. Dysregulation of caspase-1 activity has been implicated in various diseases, including chronic inflammation, septic shock, impaired wound healing, and certain leukemias, highlighting significance in both normal physiology and disease mechanisms. The human CASP1 gene, located on chromosome 2q14, encodes a cytoplasmic protein expressed in key tissues such as the liver, heart, skeletal muscle, kidney, and testis. By providing reliable detection of caspase-1 in various forms, caspase-1 (D-3) antibody is an indispensable tool for researchers investigating the intricate roles of this enzyme in immune responses and apoptotic pathways. Available in both non-conjugated and multiple conjugated forms, anti-caspase-1 antibody (D-3) facilitates versatile experimental approaches to elucidate the complex biology of caspase-1.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-1 Antibody (D-3) | sc-392736 | 200 µg/ml | $322.00 | |||
caspase-1 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-530332 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-1 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-523771 | 200 µg Ab, 40 µg BP | $361.00 | |||
caspase-1 Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-543994 | 200 µg Ab; 20 µg BP | $361.00 | |||
caspase-1 Antibody (D-3) AC | sc-392736 AC | 500 µg/ml, 25% agarose | $424.00 | |||
caspase-1 Antibody (D-3) HRP | sc-392736 HRP | 200 µg/ml | $322.00 | |||
caspase-1 Antibody (D-3) FITC | sc-392736 FITC | 200 µg/ml | $336.00 | |||
caspase-1 Antibody (D-3) PE | sc-392736 PE | 200 µg/ml | $349.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 488 | sc-392736 AF488 | 200 µg/ml | $364.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 546 | sc-392736 AF546 | 200 µg/ml | $364.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 594 | sc-392736 AF594 | 200 µg/ml | $364.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 647 | sc-392736 AF647 | 200 µg/ml | $364.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 680 | sc-392736 AF680 | 200 µg/ml | $364.00 | |||
caspase-1 Antibody (D-3) Alexa Fluor® 790 | sc-392736 AF790 | 200 µg/ml | $364.00 | |||
caspase-1 (D-3) Neutralizing Peptide | sc-392736 P | 100 µg/0.5 ml | $69.00 |