casein kinase IIβ Antibody (E-9): sc-46666
- casein kinase IIβ Antibody (E-9) is a mouse monoclonal IgG1 κ, cited in 17 publications, provided at 200 µg/ml
- raised against amino acids 1-215 representing full length casein kinase IIβ of human origin
- recommended for detection of casein kinase IIβ of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- See casein kinase IIβ (6D5): sc-12739 for casein kinase IIβ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for casein kinase IIβ Antibody (E-9) for WB and IHC(P) applications. These reagents are now offered in bundles with casein kinase IIβ Antibody (E-9) (see ordering information below).
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casein kinase IIβ Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects casein kinase IIβ in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Casein kinase IIβ plays a crucial role in cellular signaling and regulation, particularly in the phosphorylation of serine and threonine residues on target proteins, which is essential for modulating various cellular processes such as cell growth, differentiation, and apoptosis. Casein kinase IIβ is predominantly located in the cytoplasm and nucleus, where casein kinase IIβ participates in critical functions like DNA replication and repair, making casein kinase IIβ vital for maintaining genomic stability. The tetrameric structure of casein kinase II, typically composed of two catalytic subunits and two regulatory subunits, allows for a high degree of functional versatility and regulation, as the β regulatory subunit enhances the activity of the catalytic subunit through autophosphorylation. This dynamic regulation is particularly important in proliferating and differentiating cells, where casein kinase IIβ is known to phosphorylate over 100 substrates, including key nuclear oncoproteins and transcription factors, thereby influencing gene expression and cellular responses to stress. Anti-casein kinase IIβ antibody (E-9) is an invaluable tool for researchers studying the intricate roles of this protein in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
casein kinase IIβ Antibody (E-9) References:
- CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling. | Yu, S., et al. 2021. J Cell Commun Signal. 15: 383-392. PMID: 33928514
- CSNK2B: A broad spectrum of neurodevelopmental disability and epilepsy severity. | Ernst, ME., et al. 2021. Epilepsia. 62: e103-e109. PMID: 34041744
- De Novo CSNK2B Mutations in Five Cases of Poirier-Bienvenu Neurodevelopmental Syndrome. | Yang, Q., et al. 2022. Front Neurol. 13: 811092. PMID: 35370893
- MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell Proliferation via a CSNK2B/CDK4 Axis. | Li, X., et al. 2023. Technol Cancer Res Treat. 22: 15330338221150544. PMID: 36617978
- Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders. | Di Stazio, M., et al. 2023. Genes (Basel). 14: PMID: 36833176
- Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B. | Azad, P., et al. 2023. J Clin Invest. 133: PMID: 37022795
- Refining of the electroclinical phenotype in familial and sporadic cases of CSNK2B-related Neurodevelopmental Syndrome. | Trivisano, M., et al. 2023. Epilepsy Behav. 147: 109436. PMID: 37717460
- Genetic analysis and literature review of a Poirier-Bienvenu neurodevelopmental syndrome family line caused by a de novo frameshift variant in CSNK2B. | Li, D., et al. 2024. Mol Genet Genomic Med. 12: e2327. PMID: 38037515
- RACK1 Promotes Meningioma Progression by Activation of NF-κB Pathway via Preventing CSNK2B from Ubiquitination Degradation. | Maalim, AA., et al. 2024. Cancers (Basel). 16: PMID: 38398158
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
casein kinase IIβ Antibody (E-9) | sc-46666 | 200 µg/ml | $322.00 | |||
casein kinase IIβ Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-536788 | 200 µg Ab; 10 µg BP | $361.00 | |||
casein kinase IIβ Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-533952 | 200 µg Ab; 40 µg BP | $361.00 | |||
casein kinase IIβ Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-544819 | 200 µg Ab; 20 µg BP | $361.00 |