casein kinase IIβ Antibody (6D5): sc-12739

Casein kinase IIβ Antibody (6D5) is a mouse monoclonal IgG1 kappa light chain antibody that detects casein kinase II beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Casein kinase IIβ (6D5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Casein kinase II beta protein plays a crucial role in cellular signaling and regulation, functioning as a serine/threonine kinase that phosphorylates a wide array of substrates, including nuclear oncoproteins and transcription factors, which are vital for controlling cell growth and differentiation. Casein kinase II beta protein is predominantly located in the cytosol and nucleus of proliferating and differentiating cells, where activity is essential for processes such as DNA replication and repair. Tetrameric structure of casein kinase II, typically composed of two alpha and two beta subunits, allows for intricate regulation of kinase activity, particularly through autophosphorylation of the beta subunit. Given involvement in phosphorylating over 100 different substrates, casein kinase II is integral to various cellular functions, making casein kinase IIβ (6D5) antibody a valuable tool for researchers studying cell signaling pathways and implications in diseases such as cancer.

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casein kinase IIβ Antibody (6D5) References:

1. Phosphorylation of type II (beta) protein kinase C by casein kinase II.  |  Tominaga, M., et al. 1991. J Biochem. 110: 655-60. PMID: 1778990
2. Casein kinase I and II--multipotential serine protein kinases: structure, function, and regulation.  |  Tuazon, PT. and Traugh, JA. 1991. Adv Second Messenger Phosphoprotein Res. 23: 123-64. PMID: 1997039
3. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.  |  Lozeman, FJ., et al. 1990. Biochemistry. 29: 8436-47. PMID: 2174700
4. CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.  |  Yu, S., et al. 2021. J Cell Commun Signal. 15: 383-392. PMID: 33928514
5. CSNK2B: A broad spectrum of neurodevelopmental disability and epilepsy severity.  |  Ernst, ME., et al. 2021. Epilepsia. 62: e103-e109. PMID: 34041744
6. Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.  |  Azad, P., et al. 2023. J Clin Invest. 133: PMID: 37022795
7. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.  |  Zhai, L., et al. 1995. J Biol Chem. 270: 12717-24. PMID: 7759525
8. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
9. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.  |  Allende, JE. and Allende, CC. 1995. FASEB J. 9: 313-23. PMID: 7896000
10. Casein kinase II in signal transduction and cell cycle regulation.  |  Litchfield, DW. and Lüscher, B. 1993. Mol Cell Biochem. 127-128: 187-99. PMID: 7935350
11. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.  |  Graves, PR., et al. 1993. J Biol Chem. 268: 6394-401. PMID: 8454611

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase IIβ Antibody (6D5) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase IIβ Antibody (6D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase IIβ Antibody (6D5) Specifications

Alternate Product Name: CSNK2B

Product Clone Name: 6D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: casein kinase IIβ

Epitope Species: human

Product Reactivity/Detection: casein kinase IIβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for casein kinase IIβ Antibody (6D5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin