Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3), and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 9 is the main transducer of Dectin-1 signals that consist of mediated myeloid cell activation, cytokine production, and innate anti-fungal immunity. Dectin-1 is the main mammalian receptor that recognizes the fungal component zymosan. CARD 9 self-associates and has coiled-coil motifs that may function as oligomerization domains. Bcl10 interacts with CARD 9 and regulates the zymosan induced NFκB activation. Overexpression of CARD 9 correlates with the development of gastric B-cell lymphoma.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.