CARD 9 Antibody (C-2): sc-374007

CARD 9 Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects CARD 9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CARD 9 plays a crucial role in the immune response, particularly in the recognition of fungal pathogens through its interaction with the Dectin-1 receptor, which is essential for myeloid cell activation and subsequent cytokine production. This interaction is vital for innate anti-fungal immunity, as it helps the body mount an effective defense against fungal infections. CARD 9 is primarily located in the cytoplasm and can translocate to the nucleus upon activation, where CARD 9 participates in the regulation of NFκB signaling pathways. Notably, CARD 9 contains coiled-coil motifs that facilitate oligomerization, a process that is critical for signal transduction. Additionally, CARD 9 has been shown to interact with Bcl10, a protein that modulates the NFκB activation pathway in response to zymosan, a component of fungal cell walls. CARD 9 overexpression has been linked to the development of gastric B-cell lymphoma, highlighting CARD 9′s significance in both immune response and disease pathology. anti-CARD 9 antibody (C-2) is an invaluable tool for researchers studying immune signaling pathways and their implications in health and disease.

The preferred CARD 9 antibody is CARD 9 Antibody (A-8): sc-374569.