CaMKIV Antibody (A-3): sc-166156

CaMKIV Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects CaMKIV in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-CaMKIV antibody (A-3) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. CaMKIV, a member of the calcium/calmodulin-dependent protein kinase family, plays a crucial role in cellular signaling pathways, particularly in T cell activation and neuronal function. CaMKIV is primarily located in the nucleus, where CaMKIV regulates gene expression and is involved in the phosphorylation of transcription factors, thereby influencing processes such as cell differentiation and proliferation. Nuclear localization of CaMKIV is essential for function, as this positioning allows direct interaction with and modification of target proteins that are critical for the transcriptional response to calcium signaling. CaMKIV is activated by calcium and calmodulin, but also requires phosphorylation by other kinases for full activation, highlighting the intricate regulatory mechanisms that govern activity. Stimulation of the T cell receptor CD3 signaling complex can lead to a significant increase in CaMKIV activity, underscoring importance in immune responses.

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CaMKIV Antibody (A-3) References:

1. Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice.  |  Ko, SW., et al. 2005. Mol Pain. 1: 10. PMID: 15813959
2. ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons.  |  Saino-Saito, S., et al. 2007. J Comp Neurol. 502: 485-96. PMID: 17394138
3. Involvement of CaMKIV in neurogenic effect with chronic fluoxetine treatment.  |  Song, N., et al. 2013. Int J Neuropsychopharmacol. 16: 803-12. PMID: 22695008
4. Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice.  |  Moriguchi, S., et al. 2015. Mol Neurobiol. 52: 1210-1222. PMID: 25316382
5. The camKK2/camKIV relay is an essential regulator of hepatic cancer.  |  Lin, F., et al. 2015. Hepatology. 62: 505-20. PMID: 25847065
6. Exploring the Role of CaMKIV in Homeostatic Plasticity.  |  Bleier, J. and Toliver, A. 2017. J Neurosci. 37: 11520-11522. PMID: 29187612
7. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.  |  Cunningham, KE., et al. 2019. FASEB J. 33: 1330-1346. PMID: 30113881
8. Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway.  |  Wang, F., et al. 2021. J Pharmacol Sci. 146: 105-115. PMID: 33941321
9. Nrf2 improves hippocampal synaptic plasticity, learning and memory through the circ-Vps41/miR-26a-5p/CaMKIV regulatory network.  |  Zhang, R., et al. 2022. Exp Neurol. 351: 113998. PMID: 35143833
10. CaMKIV mediates spine growth deficiency of hippocampal neurons by regulation of EGR3/BDNF signal axis in congenital hypothyroidism.  |  Wu, H., et al. 2022. Cell Death Discov. 8: 482. PMID: 36473844

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaMKIV Antibody (A-3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CaMKIV Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaMKIV Antibody (A-3) Specifications

Alternate Product Name: CAMK4

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 423-461

Epitope Target: CaMKIV

Epitope Species: human

Product Reactivity/Detection: CaMKIV and Calspermin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CaMKIV Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred CaMKIV antibody is CaMKIV Antibody (H-5): sc-55501.