CA VI Antibody (F-12): sc-166679
- CA VI Antibody (F-12) is a mouse monoclonal IgG2b κ CA VI antibody provided at 200 µg/ml
- raised against a peptide mapping near the N-terminus of Carbonic Anhydrase VI of human origin
- CA VI Antibody (F-12) is recommended for detection of precursor and mature CA VI of human origin by WB, IP, IF and ELISA
- Anti-CA VI Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CA VI Antibody (F-12) for WB applications. These reagents are now offered in bundles with CA VI Antibody (F-12) (see ordering information below).
CA VI Antibody (F-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects CA VI protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CA VI antibody (F-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Carbonic anhydrase VI (CA VI) plays a crucial role in taste perception by being secreted in saliva, where CA VI protects taste receptor cells from apoptosis, thereby maintaining their functionality. CA VI is primarily located in the salivary glands and is secreted into the oral cavity, which is vital for its protective role in taste function. Notably, CA VI exists as a single polypeptide chain that is tightly bound to a zinc ion, and CA VI features two N-linked glycosylation sites that are essential for stability and activity. A decrease in CA VI secretion has been linked to various taste disorders, such as hypogeusia and dysgeusia, highlighting the importance of CA VI in sensory perception. Studies have shown that supplementing zinc in individuals with taste dysfunction can restore CA VI secretion to normal levels, suggesting that zinc plays a significant role in the regulation of this enzyme and its associated functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CA VI Antibody (F-12) References:
- Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency. | Henkin, RI., et al. 1999. Am J Med Sci. 318: 392-405. PMID: 10616164
- Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands. | Leinonen, J., et al. 2001. J Histochem Cytochem. 49: 657-62. PMID: 11304804
- Radioimmunoassay of carbonic anhydrase VI in saliva and sheep tissues. | Fernley, RT., et al. 1991. Biochem J. 274 (Pt 2): 313-6. PMID: 1900985
- The gene for human carbonic anhydrase VI(CA6) is on the tip of the short arm of chromosome 1. | Sutherland, GR., et al. 1989. Cytogenet Cell Genet. 50: 149-50. PMID: 2505973
- Circadian periodicity in salivary carbonic anhydrase VI concentration. | Parkkila, S., et al. 1995. Acta Physiol Scand. 154: 205-11. PMID: 7572216
- Competitive time-resolved immunofluorometric assay for quantifying carbonic anhydrase VI in saliva. | Parkkila, S., et al. 1993. Clin Chem. 39: 2154-7. PMID: 8403401
- Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II. | Ogawa, Y., et al. 1993. J Histochem Cytochem. 41: 343-51. PMID: 8429198
- Secretory carbonic anhydrase isoenzyme (CA VI) in human serum. | Kivelä, J., et al. 1997. Clin Chem. 43: 2318-22. PMID: 9439449
- Gustin from human parotid saliva is carbonic anhydrase VI. | Thatcher, BJ., et al. 1998. Biochem Biophys Res Commun. 250: 635-41. PMID: 9784398
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA VI Antibody (F-12) | sc-166679 | 200 µg/ml | $316.00 | |||
CA VI Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-521708 | 200 µg Ab, 40 µg BP | $354.00 | |||
CA VI Antibody (F-12): m-IgG2b BP-HRP Bundle | sc-548954 | 200 µg Ab; 10 µg BP | $354.00 | |||
CA VI Antibody (F-12) AC | sc-166679 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CA VI Antibody (F-12) HRP | sc-166679 HRP | 200 µg/ml | $316.00 | |||
CA VI Antibody (F-12) FITC | sc-166679 FITC | 200 µg/ml | $330.00 | |||
CA VI Antibody (F-12) PE | sc-166679 PE | 200 µg/ml | $343.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 488 | sc-166679 AF488 | 200 µg/ml | $357.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 546 | sc-166679 AF546 | 200 µg/ml | $357.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 594 | sc-166679 AF594 | 200 µg/ml | $357.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 647 | sc-166679 AF647 | 200 µg/ml | $357.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 680 | sc-166679 AF680 | 200 µg/ml | $357.00 | |||
CA VI Antibody (F-12) Alexa Fluor® 790 | sc-166679 AF790 | 200 µg/ml | $357.00 | |||
CA VI (F-12) Neutralizing Peptide | sc-166679 P | 100 µg/0.5 ml | $68.00 |