Blk Antibody (G-5): sc-376597
- Blk Antibody (G-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 21-53 at the N-terminus of Blk of mouse origin
- recommended for detection of Blk of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Blk Antibody (G-5) for WB applications. These reagents are now offered in bundles with Blk Antibody (G-5) (see ordering information below).
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Blk Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects Blk in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Blk, or B lymphocyte kinase, is a crucial protein that plays a significant role in the signaling pathways of B lymphocytes, which are essential for the adaptive immune response. Blk (G-5) antibody targets proteins primarily located in the cytoplasm of B cells, where Blk is involved in the regulation of B cell receptor signaling, influencing processes such as cell proliferation, differentiation, and survival. The proper functioning of Blk is vital for maintaining immune homeostasis, and dysregulation of Blk activity can lead to various immunological disorders, including autoimmune diseases and lymphomas. Anti-Blk antibody (G-5) provides reliable detection and analysis of Blk, facilitating research into B cell biology and implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Blk Antibody (G-5) References:
- The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. | Texido, G., et al. 2000. Mol Cell Biol. 20: 1227-33. PMID: 10648608
- Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein. | Delgado-Vega, AM., et al. 2012. Ann Rheum Dis. 71: 1219-26. PMID: 22696686
- Influence of BLK polymorphisms on the risk of rheumatoid arthritis. | Zhang, H., et al. 2012. Mol Biol Rep. 39: 9965-70. PMID: 22740142
- Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. | Bonnefond, A., et al. 2013. Diabetologia. 56: 492-6. PMID: 23224494
- Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis. | Génin, E., et al. 2013. PLoS One. 8: e61044. PMID: 23646104
- Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels. | Wu, YY., et al. 2015. J Immunol. 194: 5692-702. PMID: 25972485
- Autoimmune disease-associated haplotypes of BLK exhibit lowered thresholds for B cell activation and expansion of Ig class-switched B cells. | Simpfendorfer, KR., et al. 2015. Arthritis Rheumatol. 67: 2866-76. PMID: 26246128
- Polymorphisms of FAM167A-BLK Region Confer Risk of Autoimmune Thyroid Disease. | Song, RH., et al. 2018. DNA Cell Biol. 37: 932-940. PMID: 30351170
- BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus. | Ramírez-Bello, J., et al. 2019. Inflamm Res. 68: 705-713. PMID: 31134304
- Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus. | Di, D., et al. 2020. J Hum Genet. 65: 675-681. PMID: 32313195
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Blk Antibody (G-5) | sc-376597 | 200 µg/ml | $322.00 | |||
Blk Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-537991 | 200 µg Ab; 10 µg BP | $361.00 | |||
Blk Antibody (G-5): m-IgGκ BP-HRP Bundle | sc-535496 | 200 µg Ab; 40 µg BP | $361.00 | |||
Blk Antibody (G-5): m-IgG1 BP-HRP Bundle | sc-545478 | 200 µg Ab; 20 µg BP | $361.00 | |||
Blk (G-5) Neutralizing Peptide | sc-376597 P | 100 µg/0.5 ml | $69.00 |